Transcriptional regulation of the human ferritin ... - The FASEB Journal
Recommend Documents
block Nrf2 nuclear accumulation but inhibited Nrf2 binding to the AREs by 40% (P
The GAL gene family, the set of structural and regulatory genes (Table. 1) that enable cells to utilize galactose as a carbon source, is one of the best-studied.
Received 10 October 1996/Returned for modification 14 November 1996/Accepted 11 December 1996 .... CCAAT binding factor NF-Y (also known as CP1 and CBF) ...... Kwak, E. L., D. A. Larochelle, C. Beaumont, S. V. Torti, and F. M. Torti.
Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by.
Tumor Progression and Metastasis Program, Barbara Ann Karmanos Cancer Institute, Wayne State. University, School of Medicine, Detroit, Michigan, USA.
Nov 15, 1985 - Human teratocarcinoma cells were used to examine structural features ... major immediate-early (IE) gene of human cytomegalovirus.
Jul 21, 2003 - .org/]) (strain COL), and the Staphylococcus aureus Sequencing Group at .... a bifunctional kinase-phosphatase; lgt encodes a prelipoprotein.
May 15, 2016 - Susan Quinones, Juan Sauss, Yoshihide Otani, Edward D. Harris, ...... Harris, E. D., Jr., Welgus, H. G., and Krane, S. M. (1984) Collagen. Relat. Res. 4, 493-512. Schmid, T. M., Mayne, R., Jeffrey, J. J., and Linsenmayer, T. F..
From the $Laboratoire de Genetique Mokculaire, Faculti Xavier Bichat, 16, rue Henri Huchard, 75018 Paris, ..... Boxed residues are considered by Ford et al.
apicomplexan parasites like Toxoplasma and Plasmo- dium and control important processes of the parasite life cycle. Despite recently reported crystal structures.
of the L-pyruvate kinase gene in a hepatoma cell line is independent of insulin and cyclic AMP. FASEBJ. 8: 89-96;. 1994. Key Words: glucose signaling pathway.
Wake Forest University Health Science, Winston-Salem, North Carolina; and ... Physiology and Biochemistry, Queen's University, Kingston, Ontario, Canada.
Transcriptional regulation of the human ferritin ... - The FASEB Journal
ferritin genes. PRMT1 or PRMT4 knockdown did not block Nrf2 nuclear accumulation but inhibited Nrf2 binding to the AREs by 40% (P
The FASEB Journal • Research Communication
Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4 Bo-Wen Huang,* Paul D. Ray,* Kenta Iwasaki,† and Yoshiaki Tsuji*,1 *Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina, USA; and †Department of Applied Immunology, Nagoya University School of Medicine, Nagoya, Japan Antioxidant genes such as ferritin are transcriptionally activated in oxidative stress via the antioxidant responsive element (ARE), to which nuclear factor-E2-related factor 2 (Nrf2) binds and activates transcription. Histone modification plays a cooperative and essential role in transcriptional regulation; however, its role in antioxidant gene transcription remains elusive. Arsenic exposure activated ferritin transcription via the ARE concomitant with increased methylation of histones H4Arg3 (H4R3) and H3Arg17 (H3R17). To test our hypothesis that histone H4R3 and H3R17 methylation regulates ferritin transcription, H4R3 and H3R17 protein arginine (R) methyltransferases 1 and 4 (PRMT1 and PRMT4) were investigated. Arsenic exposure of human HaCaT keratinocytes induced nuclear accumulation of PRMT1 and PRMT4, histone H4R3 and H3R17 methylation proximal to the ARE, but not to the non-ARE regions of ferritin genes. PRMT1 or PRMT4 knockdown did not block Nrf2 nuclear accumulation but inhibited Nrf2 binding to the AREs by ⬃40% (P
