angiogenesis in vivo and stimulation of collagen formation in vitro. ANITA B. ROBERTS*, MICHAEL B. SPORN*, RICHARD K. ASSOIAN*, JOSEPH M. SMITH*, ...
Proc. Nati. Acad. Sci. USA Vol. 83, pp. 4167-4171, June 1986 Biochemistry
Transforming growth factor type ,8: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro ANITA B. ROBERTS*, MICHAEL B. SPORN*, RICHARD K. ASSOIAN*, JOSEPH M. SMITH*, NANETTE S. ROCHE*, LALAGE M. WAKEFIELD*, URSULA I. HEINE*, LANCE A. LIOTrA*, VINCENT FALANGAt, JOHN H. KEHRL*, AND ANTHONY S. FAUCIt *National Cancer Institute, Bethesda, MD 20892; tUniversity of Pittsburgh School of Medicine, Pittsburgh, PA 15213; and tNational Institute of Allergy and Infectious Diseases, Bethesda, MD 20892
Communicated by Roy Hertz, February 24, 1986
ABSTRACT Transforming growth factor type (3 (TGF-f3), when injected subcutaneously in newborn mice, causes formation of granulation tissue (induction of angiogenesis and activation of fibroblasts to produce collagen) at the site of injection. These effects occur within 2-3 days at dose levels of
