Jun 16, 1997 - in Immune Cells Develop a Severe AIDS-Like Disease ... same cells of Tg mice as those usually found infected in HIV-. 1-positive ..... showed follicular regression. ..... macrophages and dendritic cells: the other infection in AIDS. .... HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in trans-.
JOURNAL OF VIROLOGY, Jan. 1998, p. 121–132 0022-538X/98/$04.0010 Copyright © 1998, American Society for Microbiology
Vol. 72, No. 1
Transgenic Mice Expressing Human Immunodeficiency Virus Type 1 in Immune Cells Develop a Severe AIDS-Like Disease ZAHER HANNA,1,2 DENIS G. KAY,1 MARC COOL,1 SERGE JOTHY,3 NAJET REBAI,1 AND PAUL JOLICOEUR1,4,5* Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7,1 Departments of Medicine2 and Microbiology and Immunology,4 Universite´ de Montre´al, Montreal, Quebec H3C 3J7, and Departments of Pathology3 and Experimental Medicine,5 McGill University, Montreal, Quebec H3G 1A4, Canada Received 16 June 1997/Accepted 16 September 1997
We have constructed transgenic (Tg) mice expressing the entire human immunodeficiency virus type 1 (HIV1) coding sequences in cells targeted by HIV-1 infection in humans. These Tg mice developed a severe AIDSlike disease leading to early death (
