Transplantation antigens in the mouse embryo. The fate of early embryo tissues transplanted to adult hosts by MICHAEL EDIDIN1. From the Department of ...
J. Embryol. cxp. Morph., Vol. 12, Part 2, pp. 309-316, June 1964 Printed in Great Britain
Transplantation antigens in the mouse embryo. The fate of early embryo tissues transplanted to adult hosts by MICHAEL EDIDIN 1 From the Department of Zoology, University College, London
WITH ONE PLATE
THE EVIDENCE for and against the presence in cells of embryo and foetal mice of transplantation antigens, the cell-bound substances provoking the rejection of allogeneic tissue homografts, rests on two classes of experiments: those relying upon serological techniques for the detection of the antigens, and those involving some test of transplantation antigen activity in intact animals. Experiments of the former class have indicated that there are no histocompatibility antigens present on the cells of most newborn or late foetal mice, but that these antigens quickly appear during the first 2 days of neo-natal life, rendering cells liable to agglutination or lysis (Pizarro, Hoecker, Rubenstein & Ramus, 1961; Moller, 1961
