Accepted Manuscript Treatment of osteoporotic intertrochanteric fractures by zoledronic acid injection combined with proximal femoral nail anti-rotation Yong Li, Wen-Bo Zhao, De-Li Wang, Qing He, Qin Li, Fu-Xing Pei, Lei Liu PII:
S1008-1275(16)30265-6
DOI:
10.1016/j.cjtee.2016.07.001
Reference:
CJTEE 169
To appear in:
Chinese Journal of Traumatology
Received Date: 10 August 2015 Revised Date:
15 May 2016
Accepted Date: 17 July 2016
Please cite this article as: Li Y, Zhao WB, Wang DL, He Q, Li Q, Pei FX, Liu L, Treatment of osteoporotic intertrochanteric fractures by zoledronic acid injection combined with proximal femoral nail anti-rotation, Chinese Journal of Traumatology (2016), doi: 10.1016/j.cjtee.2016.07.001. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT Original article Received: 10 August 2015 Revised: 15 May 2016 Accepted: 17 July 2016
RI PT
Treatment of osteoporotic intertrochanteric fractures by zoledronic acid injection combined with proximal femoral nail anti-rotation Yong Li a,b , Wen-Bo Zhaob，De-Li Wang a，Qing Hea，Qin Lib，Fu-Xing Peib，Lei Liu b* aDepartment bDepartment
of Orthopedics, Navy General Hospital of PLA, Bejing, China
of Orthopedics, West China Hospital, Sichuan University, Chengdu,
SC
China
M AN U
*Corresponding author: Tel: +86-28-85422426，Email:
[email protected]
[Abstract]
Objective: To observe the clinical results of proximal femoral nail anti-rotation (PFNA) combined with zoledronic acid injection in the treatment of osteoporotic intertrochanteric fractures in the elderly.
TE D
Methods: 60 elderly patients with osteoporotic intertrochanteric fractures were diagnosed using a dual energy X-ray bone density instrument. Patients were randomly divided into treatment or control groups (30 cases in each group).
EP
Patients in both groups were treated by closed/open reduction and internal fixation using PFNA. In the treatment group, patients received one zoledronic phosphonic acid injection of 5 mg / 100 ml via intravenous drip, in addition to
AC C
600 mg of Caltrate D（qd）and 0.25 µg of alpha ossification alcohol（qd）. The control group received 600 mg of Caltrate D (qd) and 0.25 µg of alpha ossification alcohol (qd). The oral drugs were administered for 12 months. Bone pain relief was observed, and changes in the bone mineral density (BMD) of the lumbar and health-side hip were recorded. Clinical results were evaluated using the Visual Analogue Scale (VAS), Harris joint function score, and Osteoporosis Quality of Life Scale (OQOLS). Results: Compared with the control group, bone pain symptoms were significantly alleviated (p
