Feb 23, 2010 - host domain GL5 to create a domain insertion protein. Using single .... Multi-dimensionality of Proteins' Free-Energy Landscapes Revealed by.
Feb 23, 2010 - its two motor domains. ... nated force generation by a single motor domain during motion. .... Daniel Huck1, Jim Sellers2, Takeshi Sakamoto1.
Feb 23, 2010 - drogen-bonded atom cluster as a fragment. The new .... that can run in real-time on a standard desktop workstation, but this is becoming.
Feb 23, 2010 - Singapore. Argentina. Saudi Arabia Kazakhstan. Cape Verde ... Income plays a critical role, but not the o
Feb 23, 2016 - And the main reason why it was not paid, we told you when we were in Opposition not to rundown the ......
Feb 23, 2010 - a combination of auto- and cross-correlations of polarized fluorescence inten- ... The technology of measurement was based on electro-mechanic principle, us- ... 1Calvin College, Grand Rapids, MI, USA, 2University of Leeds,.
Feb 23, 2016 - And the main reason why it was not paid, we told you when we were in Opposition not to rundown the ......
Feb 28, 2017 - After the 2016 Budget, the Office for Budget. Responsibility found that, 'the government is on track by 2
For indoor cycle and fitball: Sign up in advance at Sports Booking (min. 16 yrs). Please collect your fitball from the I
Feb 23, 2003 - Bernard Cosell and David Walden. Because .... to find Jerry Burchfiel and Ray Tomlinson. ... Tomlinson and possibly others) and published the.
Sign up in SB. Social walk at Plaza Rambla. 30 Minutes off road run. Meet at Plaza Rambla. Social walk at Plaza Rambla.
17.00. Stretch and Relax at MC1. Stretch and Relax at MC1. Social Floorball at Indoor Hall. (min 16 yrs). Stretch and Re
Feb 23, 2010 - pophysial Excitability. Joseph L. Foley, Martin Muschol. ... Kelly Kettleson1, Meena Padha1, Ivan Quesada2, Pedro Verdugo1. 1University of ...
502a
Tuesday, February 23, 2010
2601-Pos Cystic Fibrosis Transmembrane Conductance Regulator in Mouse Pancreatic Beta-Cells Anna Edlund. Dep. of clinical sciencies, Malmo¨, Sweden. Cystic fibrosis (CF) is a monogenic autosomal recessive disease caused by mutation in the cystic fibrosis gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR), which is an ion-channel that conducts negatively charged chloride ions. Cystic fibrosis related diabetes (CFRD) is the leading complication of CF and exocrine pancreatic dysfunction affects ~85% of patients. Recently, it was discovered that rat a-cells and b-cells in the islets of Langerhans express both CFTR mRNA and protein. The aim of this study was to investigate the presence of active CFTR channels in pancreatic b-cells and if these influence insulin secretion. For this purpose we have used the patch-clamp technique and capacitance measurements on single mouse b-cells and insulin secretion measurements using RIA. First we measured the presence of CFTR in b-cells using the patch-clamp technique. A membrane conductance of 0.05 5 0.01 nS/pF (n=10) and 1.05 5 0.22 nS/pF at negative and positive potentials, respectively, was activated by the cAMP-increasing agent forskolin. The conductance was significantly reduced (P
