HLA-DRB1*, HLA-DQA1*, and HLA-DQB1* alleles in Peruvian patients with rheumatoid arthritis. F Castro, E Acevedo, E Ciusani,* J A Angulo, F A Wollheim, ...
Ann Rheum Dis 2001;60:791–795
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Tumour necrosis factor microsatellites and HLA-DRB1*, HLA-DQA1*, and HLA-DQB1* alleles in Peruvian patients with rheumatoid arthritis F Castro, E Acevedo, E Ciusani,* J A Angulo, F A Wollheim, M Sandberg-Wollheim
Hospital Central FAP, Lima, Peru F Castro J A Angulo G Almenara Hospital ESSALUD, Lima, Peru E Acevedo Department of Neurology, University Hospital, S-221 85 Lund, Sweden E Ciusani M Sandberg-Wollheim Department of Rheumatology, University Hospital, Lund F A Wollheim *Present address: Istituto Nationale Neurologico “Carlo Besta”, Milano, Italy Correspondence to: Dr M Sandberg-Wollheim Magnhild.Sandberg-Wollheim@ neurol.lu.se Accepted 15 December 2000
Abstract Objective—To study the association between rheumatoid arthritis (RA) and HLA and tumour necrosis factor (TNF) polymorphism in Peruvian mestizo patients in comparison with ethnically similar controls. Methods—Seventy nine patients with RA and 65 ethnically matched healthy controls were genotyped for HLA-DRB1, HLA-DQA1, HLA-DQB1, and TNFá and TNFâ alleles using PCR amplification. Clinical severity was assessed as mild, moderate, or severe in 35 of the patients. Results—TNFá6 showed the strongest association with disease susceptibility. The TNFá6 allele was more common in patients than in controls (p
