Unintentional methadone and buprenorphine exposures in children ...

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material based on an analysis of calls to the NYC Poison Control Center ... Approximately one-fourth of the calls came from the home and were made by the ...
SCIENCE AND PRACTICE Journal of the American Pharmacists Association 57 (2017) S83eS86

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RESEARCH NOTES

Unintentional methadone and buprenorphine exposures in children: Developing prevention messages Lauren Schwartz*, Maria Mercurio-Zappala, Mary Ann Howland, Robert S. Hoffman, Mark K. Su a r t i c l e i n f o

a b s t r a c t

Article history: Received 16 August 2016 Accepted 19 January 2017

Objectives: To develop key messages for methadone and buprenorphine safety education material based on an analysis of calls to the NYC Poison Control Center (NYC PCC) and designed for distribution to caregivers of young children. Methods: Retrospective review of all calls for children 5 years of age and younger involving methadone or buprenorphine from January 1, 2000, to June 15, 2014. A data abstraction form was completed for each case to capture patient demographics, exposure and caller sites, caller relation to patient, qualitative information regarding the exposure scenario, the product information, if naloxone was given, and the medical outcome of the case. Results: A total of 123 cases were identified. The ages of the children ranged from 4 days to 5 years; 55% were boys. All exposures occurred in a home environment. The majority of the calls were made to the NYC PCC by the doctor (74%) or nurse (2%) at a health care facility. Approximately one-fourth of the calls came from the home and were made by the parent (22%) or grandparent (2%). More than one-half of the exposures involved methadone (64%). Naloxone was administered in 28% of cases. Approximately one-fourth of the children did not experience any effect after the reported exposure, one-half (51%) experienced some effect (minor, moderate, or major), and there was 1 death (1%). More than one-half of the children were admitted to the hospital, with 40% admitted to critical care and 13% to noncritical care. Approximately 23% were treated and released from the hospital, and 20% were lost to followup or never arrived to the hospital. The remaining 4% were managed on site without a visit to the hospital. Conclusion: Exposures to methadone and buprenorphine are dangerous with some leading to serious health effects. Safe storage and disposal instructions are needed for homes where children may be present. Published by Elsevier Inc. on behalf of the American Pharmacists Association.

The New York City Poison Control Center (NYC PCC) provides treatment advice about poison exposures and medicine safety information 24 hours a day, 7 days a week (1-800-2221222 or 212-POISONS). Calls are answered by registered pharmacists and nurses certified in poison information; they are free of charge and confidential. Translation services are available for more than 150 languages.

Disclosure: The authors declare no relevant conflicts of interest or financial relationships. Previous presentation: Presented as a poster at the North American Congress of Clinical Toxicology, New Orleans, LA, October 17-21, 2014. * Correspondence: Lauren Schwartz, MPH, NYC Poison Control Center, Bellevue Hospital Center, 455 First Ave., New York, NY 10016. E-mail address: [email protected] (L. Schwartz).

Nationally, there are 55 certified PCCs that provide similar services. Each year, more than 2 million calls are made involving intentional and unintentional poisoning exposures; more than 1 million involve children 5 years of age and younger. The majority of calls involving young children are unintentional (unsupervised) exposures. Unintentional ingestion of prescription medicines by children under 6 years of age has resulted in an increase of both calls to PCCs and emergency department visits.1-3 Calls to PCCs involving pediatric exposures to methadone have continued to increase since 2000, and there has been a dramatic rise in the number of pediatric exposures to buprenorphine reported to PCCs.1 From 2007 to 2011, an annual estimate of 34,503 emergency department visits resulted from unsupervised ingestion of oral prescription medicines in children under the age of

http://dx.doi.org/10.1016/j.japh.2017.01.015 1544-3191/Published by Elsevier Inc. on behalf of the American Pharmacists Association.

SCIENCE AND PRACTICE L. Schwartz et al. / Journal of the American Pharmacists Association 57 (2017) S83eS86

6 years; unintentional buprenorphine ingestion accounted for the highest rate of hospitalizations.3 From 2004 to 2011, emergency department visits rose for exposures to buprenorphine in children under 6 years of age.4 Conversely, from 2013 to 2015, emergency department visits for ingestion of buprenorphine and naloxone in children decreased after introduction of child-resistant single-dose packaging changes.5 Increased access to methadone and buprenorphine in households leads to greater risk for potentially serious exposures among young children.1,6,7 Patient counseling and education about the danger of both methadone and buprenorphine exposures to young children is recommended.1,4,6,8-13 Several studies have examined safe storage practices of methadone in the home.8,14-16 Unfortunately, patients often do not remember receiving information about safe storage when receiving methadone.8,14,16 Objective The purpose of the present study was to develop key messages for methadone and buprenorphine safety education material based on an analysis of calls to the NYC PCC and designed for distribution to caregivers of young children. Methods A retrospective review was conducted of calls made to the NYC PCC from January 1, 2000, to June 15, 2014, involving children 5 years of age and younger and reported exposure to either methadone or buprenorphine in the home setting. For each case, a data abstraction form was completed to capture patient demographics, exposure and caller sites, caller relation to patient, qualitative information regarding the exposure scenario, the product information, if naloxone was given, and the medical outcome of the case. Outcomes were defined as no effect, minor effect (the patient showed some symptoms but they were minimally bothersome), moderate effect (patient had pronounced or prolonged symptoms because of the exposure but they were not life threatening), major effect (patient exhibited symptoms as a result of the exposure that were life threatening or resulted in significant disability or disfigurement), and death.17 Qualitative scenario information was categorized based on key words in the notes section of each case. The data were reviewed by 2 independent reviewers. The study was approved by the NYC Department of Health and Mental Hygiene Institutional Review Board. Results A total of 123 cases were analyzed. The ages of the children ranged from 4 days to 5 years; more than one-half (67, 55%) were boys. Almost all exposures occurred in the child's home (117, 95%), and a small number occurred in another residence (3, 2%). The majority of calls were made to the NYC PCC by a health care providerdeither a doctor (86, 74%) or a nurse (2, 2%)dand originated at the facility treating the patient. Approximately one-fourth of the PCC calls originated in the home and were made by the parent (25, 22%) or grandparent (2, 2%). Nearly two-thirds of the exposures involved methadone (76, 63%). Naloxone was administered in 34 cases (28%). The medical outcomes of the cases are presented in Table 1. In S84

Table 1 Medical outcomes Outcome No effect Minor effect Moderate effect Major effect Death Potentially toxic, unable to be followed Nontoxic exposure Not followed because minimally toxic exposure Unrelated effect Nonexposure Total

n

%

27 18 29 15 1 28

22% 15% 22% 12% 1% 23%

1 1

1% 1%

2 1 123

2% 1% 100%

27 cases (22%), the children did not experience any effect after the reported exposure. One-half of the children experienced some effect (minor [18, 15%], moderate [29, 24%], or major [15, 12%]) and there was 1 death (1%). Twenty-eight (23%) were noted as potentially toxic exposures but were unable to be followed. The remaining cases were judged to be nontoxic exposure (1, 1%), not followed because minimally toxic exposure (1, 1%), unrelated effect (2, 2%), and nonexposure (1, 1%). More than one-half of the exposed children were admitted to the hospital, with 49 (40%) admitted to critical care and 15 (13%) to noncritical care. Twenty-eight (23%) were treated and released from the hospital, and 26 (21%) were lost to follow-up or never arrived at the hospital. The remaining 5 (4%) were managed on site without a visit to the hospital. A review of the qualitative scenario information provided for the cases showed that 86 (70%) were described only as ingestion of either methadone or buprenorphine, but in most of the cases the details leading up to the exposure were not provided. In addition, improper storage of methadone liquid was described in 14 cases (11%). Of these, 9 involved storage of the medication in a beverage container or drinking glass and 5 exposures occurred when the child obtained the medication from the refrigerator. The remaining 23 cases (19%) were reported as medication intended for a pet (6, 5%), ingested film strip (3, 2%), withdrawal symptoms question (3, 2%), exposure to patch (2, 2%), dosing error (2, 2%), and possible exposure through breast milk (2, 2%), with 5 cases listed as unknown exposures. Discussion Our analysis found that one-half of the exposures resulted in hospital admission and 1 child died. Safe storage and patient education initiatives should be emphasized to keep children safe from exposures to medications, particularly with methadone and buprenorphine, which are associated with serious and even fatal outcomes. Although it is imperative to provide information to parents and caregivers taking methadone or buprenorphine, exposures also happen when children visit other homes or visitors bring their medications into the home. Exposures to medications can occur when medications are transferred to beverage containers and mistakenly ingested. Children may find a lost or discarded tablet, open container, or partially filled cup of medication.17,18 It is important that when young children visit or are supervised by grandparents or

SCIENCE AND PRACTICE Methadone and buprenorphine prevention messages

Safe Storage of Methadone and Buprenorphine

Methadone Liquid

Methadone Tablets

Buprenorphine Tablets

A small amount of methadone or buprenorphine is extremely dangerous especially to a child

• NEVER store liquid methadone in a beverage container. • ALWAYS keep these medicines stored in the original container. • ALWAYS keep these medicines out of sight and out of reach of children in a locked box or cabinet. • CALL the NYC Poison Control Center right away at 212-POISONS (212-764-7667) if you think someone has ingested these medicines. • CALL the Poison Control Center to find out the safest way to dispose of these medicines.

Registered pharmacists and nurses provide information 24 hours a days a week.

Figure 1. Safe storage of methadone and buprenorphine card.

other caregivers who are taking dangerous medications, additional steps are addressed to reduce the risk of exposure.18 More research is needed to provide best practices for families to ensure safe storage and disposal of opioids.19 Pharmacists are in an ideal position to provide an essential role and ensure that safe storage and disposal methods are understood by the patient. Pharmacists should discuss the risks of opioids with family members and others who visit the home. In addition, the importance of not sharing medications should be emphasized. Safe disposal methods are often unclear and unknown to patients.19 Both written and verbal instructions about safe storage of methadone are important at intake for treatment as well as the period when take-home methadone maintenance is initiated.13,14,16,19,20 Safe storage involves keeping opioids in a portable lock box or locked medicine cabinet in the home. This is a low-cost method that reminds adults about the risks of opioids and helps to create a barrier to access these medications.1,16,19,20 Additional research of community-based poison prevention interventions are needed to understand ways to reduce childhood poisonings and poisoning rates and establish best practices.21,22 In addition, more targeted prevention programs should focus on medications with the highest rates of pediatric hospitalizations after unintentional ingestions to achieve the most public health impact.3 The risks of these medicines and the importance of medicine safety should be explained to parents and others involved in the care of young children who may be exposed to methadone and buprenorphine.1,6,7,9-11,15,17,20 Providers should remind patients to keep medicines in their original containers with child-resistant packaging and out of sight and to post the PCC number in their homes.4,10 In addition to recommending safe opioid storage to prevent unintentional poisonings to children 5 years of age and younger, it must emphasized that these medications also pose a danger of abuse by older children.12,19 It is important to emphasize that a small amount of methadone or

buprenorphine is dangerous and even fatal to a child.9,11,17 The efforts to encourage safe storage of methadone may also affect safe storage with all medications.13 Based on the literature and the present study's findings, key messages for the methadone and buprenorphine safety information should emphasize the following: a small amount is dangerous, even fatal, if ingested; and safe storage in a locked location and in child-resistant packaging can prevent injury. The NYC PCC staff is available 24 hours a day, 7 days a week to provide advice about medicines, including potential exposures, side effects, interactions, and safe disposal recommendations. The PCC developed a multilingual educational card to be distributed through methadone maintenance programs and providers treating patients with the use of buprenorphine that provides prevention messages (Figure 1). Additional research is needed to evaluate the implementation of the safety education and the reduction of unintentional exposures to methadone and buprenorphine in children.

Limitations This study was conducted with the use of NYC PCC call data and may not capture all exposures to methadone and buprenorphine if the case was not reported to the NYC PCC. In addition, many cases did not contain enough detail about the exposure to reliably ascertain all factors contributing to the child's exposure and may not represent actual ingestions. Cases are solely obtained by report by the patient's caregiver or health care provider to the NYC PCC. The majority of calls were from health care providers and details of the poisoning exposure in the home may not have been reported. There was no review of patient medical records. This is a sample from 1 PCC's experience, and the results may not be applicable elsewhere. In addition, the present study did not evaluate the safety card as an intervention. S85

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Conclusion Exposures to methadone and buprenorphine are dangerous to children in small quantities and may lead to serious health effects or even death. Safe storage and disposal instructions are essential for patients who have young children in the home. Further research is needed to assess efficacy of these educational efforts and to determine if risk of childhood exposures to methadone and buprenorphine are reduced.

References 1. Boyer EW, McCance-Katz EF, Marcus S. Methadone and buprenorphine toxicity in children. Am J Addict. 2010;19(1):89e95. 2. Budnitz DS, Salis S. Preventing medication overdoses in young children: an opportunity for harm elimination. Pediatrics. 2011;127(6):e1597ee1599. 3. Lovegrove MC, Mathew J, Hampp C, et al. Emergency hospitalizations for unsupervised prescription medication ingestions by young children. Pediatrics. 2014;134(4):e1009ee1016. 4. Lovegrove MC, Hampton LM, Budnitz DS, et al. Notes from the field: Emergency department visits and hospitalizations for buprenorphine ingestion by childrendUnited States, 2010-2011. MMWR Morb Mortal Wkly Rep. 2013;62(3):56. 5. Budnitz DS, Lovegrove MC, Sapiano MR, et al. Notes from the field: pediatric emergency department visits for buprenorphine/naloxone ingestiondUnited States, 2008-2015. MMWR Morb Mortal Wkly Rep. 2016;65(41):1148e1149. 6. Pedapati EV, Bateman ST. Toddlers requiring pediatric intensive care unit admission following at-home exposure to buprenorphine/naloxone. Pediatr Crit Care Med. 2011;12(2):e102ee107. 7. Soyka M. Buprenorphine and buprenorphine/naloxone intoxication in childrendhow strong is the risk? Curr Drug Abuse Rev. 2013;6(1):63e70. 8. Calman L, Finch E, Powis B, et al. Methadone treatment. Only half of patients store methadone in safe place. BMJ. 1996;313(7070):1481. 9. Geib AJ, Babu K, Ewald MB, et al. Adverse effects in children after unintentional buprenorphine exposure. Pediatrics. 2006;118(4):1746e1751. 10. Thomas K, Malheiro M, Crouch BI. Buprenorphine prescribing practices and exposures reported to a poison centerdUtah, 2002-2011. MMWR Morb Mortal Wkly Rep. 2012;61(49):997e1001. 11. Kim HK, Smiddy M, Hoffman RS, et al. Buprenorphine may not be as safe as you think: a pediatric fatality from unintentional exposure. Pediatrics. 2012;130(6):e1700ee1703.

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12. Tadros A, Layman SM, Davis SM, et al. Emergency department visits by pediatric patients for poisoning by prescription opioids. Am J Drug Alcohol Abuse. 2016;42(5):550e555. 13. Williams N, Robertson J, McGorm K, et al. What factors affect medicationstorage practice among patients on methadone maintenance treatment? Int J Pharm Pract. 2009;17(3):165e169. 14. Bloor RN, McAuley R, Smalldridge N. Safe storage of methadone in the homedan audit of the effectiveness of safety information giving. Harm Reduct J. 2005;2:9. 15. Winstock AR, Lea T. Safe storage of methadone takeaway doses - a survey of patient practice. Aust N Z J Public Health. 2007;31(6):526e528. 16. Mullin A, McAuley RJ, Watts DJ, et al. Awareness of the need for safe storage of methadone at home is not improved by the use of protocols on recording information giving. Harm Reduct J. 2008;5:15. 17. Bailey JE, Campagna E, Dart RC. The underrecognized toll of prescription opioid abuse on young children. Ann Emerg Med. 2009;53(4):419e424. 18. Lavonas EJ, Banner W, Bradt P, et al. Root causes, clinical effects, and outcomes of unintentional exposures to buprenorphine by young children. J Pediatr. 2013;163(5):1377e1383.e1-e3. 19. Binswanger IA, Glanz JM. Pharmaceutical opioids in the home and youth: implications for adult medical practice. Subst Abuse. 2015;36(2): 141e143. 20. Marcus SM. Accidental death from take home methadone maintenance doses: a report of a case and suggestions for prevention. Child Abuse Negl. 2011;35(1):1e2. 21. Nixon J, Spinks A, Turner C, et al. Community based programs to prevent poisoning in children 0-15 years. Inj Prev. 2004;10(1):43e46. 22. Kendrick D, Smith S, Sutton A, et al. Effect of education and safety equipment on poisoning-prevention practices and poisoning: systematic review, meta-analysis and meta-regression. Arch Dis Child. 2008;93(7): 599e608. Lauren Schwartz, MPH, Director of Public Education, NYC Poison Control Center, Bellevue Hospital Center, New York, NY Maria Mercurio-Zappala, RPh, MS, Associate Director, NYC Poison Control Center, Bellevue Hospital Center, New York, NY Mary Ann Howland, PharmD, Clinical Professor of Pharmacy, St. John's University College of Pharmacy and Health Sciences, Queens, NY, and NYC Poison Control Center, Bellevue Hospital Center, New York, NY Robert S. Hoffman, MD, Director, Division of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, New York University School of Medicine, New York, NY Mark K. Su, MD, MPH, Director, NYC Poison Control Center, NYC Department of Health and Mental Hygiene, New York, NY