Upper Airway Resistance Syndrome: Effect of Nasal Dilation, Sleep ...
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Upper Airway Resistance Syndrome: Effect of Nasal Dilation, Sleep ...
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UPPER AIRWAY RESISTANCE SYNDROME
Upper Airway Resistance Syndrome: Effect of Nasal Dilation, Sleep Stage, and Sleep Position Ahmed S. Bahammam MD, MRCP; Robert Tate MSC; Jure Manfreda MD and Meir H. Kryger MD, FRCPC Sleep Disorders Centre, St. Boniface General Hospital, Section of Respiratory Diseases and Department of Medicine, and the Department of Community Health Sciences, University of Manitoba, Winnipeg, Manitoba Background: The upper airway resistance syndrome (UARS) is one of the mild variants of obstructive sleep disordered breathing. Nasal obstruction is proposed as one of the mechanisms that lowers intrapharyngeal pressure and hence increases airway collapsibility. Objective: We evaluated the effect of external nasal dilation and sleep position on sleep in UARS. Method: A double blind, randomized, controlled study with a crossover design (using therapeutic and placebo dilators) was conducted in 18 consecutive patients with UARS. Each patient had two overnight sleep studies one to two weeks apart. Cardiorespiratory parameters (AHI, percentage of time that SaO2 was more than 2% below awake [desaturation time] and mean overnight heart rate), sleep architecture (sleep stages, sleep efficiency, and arousal index), and body position were determined. Results: Application of the external nasal dilator resulted in a significant increase in the nasal cross-sectional area (p
