PERSONAL EXPERIENCE ON A COHORT OF 106 PREGNANT WOMEN WITH RHEUMATIC DISEASES. F. De Leonardis1, S. Giacuzzo1, G. Castellino1, ...
[AB0864] UTERINE ARTERIES DOPPLER VELOCIMETRY AS PREDICTOR OF PREGNANCY OUTCOME: PERSONAL EXPERIENCE ON A COHORT OF 106 PREGNANT WOMEN WITH RHEUMATIC DISEASES F. De Leonardis 1, S. Giacuzzo 1, G. Castellino 1, M. Padovan1, R. Capucci2, F. Trotta 1, M. Govoni1. 1
Section of Rheumatology, Department of Clinical and Experimental Medicine, Azienda
Ospedaliera Universitaria Ospedale S.Anna, University of Ferrara; 2Department of Obstetrics and Gynecology, Azienda Ospedaliera Universitaria S.Anna, Ferrara, Italy Background: To evaluate influence on pregnancy outcome of an impaired wave uterine-arteries Doppler velocimetry in patients affected by several rheumatic diseases. Objectives: A prospective study by applying a transabdominal doppler ultrasound was performed in a cohort of pregnant women who consecutively attended our clinic from January 2004 to january 2009 for different rheumatic diseases: systemic lupus erythematosus (SLE), undifferentiated connective tissue disease (UC TD), primary antiphospholipid syndrome (APS), systemic sclerosis (SSc), seronegative spondyloarthritis (SpA), Sjogren Syndrome (SS), Behcet's disease (BD) and Rheumatoid Arthritis (RA). In all the cases, the demographic and clinical data about the patients, as well as the pregnancy outcomes were recorded. Resistance index (RI) of uterine arteries was measured every 4 weeks from 21 to 32 weeks gestation. The statistical analysis was performed using the Mann Whitney test for continuous variables and the Fisher's exact test for categorical variables. Methods: We recorded data about 110 pregnancies on a group of 106 patients (37 with UC TD, 25 with SLE, 12 with APS, 10 with SS, 8 with RA, 6 with SSc, 5 with SpA, 3 with BD). The demographic and clinical features of the studied cohort, as well as the pregnancy outcomes are summarized in table 1. Results:
Median age (years)
Pregnancies with altered UAD
Pregnancies with normal UAD
Total = 36 (32.7%)
Total = 74 (67.3%)
35 (range: 44-23)
p
34 (range: 43-26)
ns
Premature membrane rupture 12 (33.3%)
6 (8.1%)
0.0017**
Pre-eclampsia
6 (16.6%)
1 (1.3%)
0.0048**
Prematurity
19 (52.7%)
11 (14.8%)
< 0.0001***
Intrauterine growth retardation
2 (5.5%)
2 (2.7%)
ns
Miscarriages
0
1 (1.3%)
ns
Median gestational age (weeks)
37 (range: 30-40)
39 (range: 28-42)
ns
Median birth weight (gr)
2860 (range: 1000-3670)
3250 (range: 1170-6230)
< 0.0001***
Normal full term delivery
16 (44.4%)
56 (75.6%)
0,0024**
Conclusion: Our study demonstrates that Doppler velocimetry of uterine arteries is a powerful tool for individuating patients at higher risk for some bad pregnancy outcomes, especially premature membrane rupture, pre-eclampsia, prematurity and low birth weight. Disclosure of Interest: None declared Citation: Ann Rheum Dis 2010;69(Suppl3):711 Session: Diagnostics and imaging procedures
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