Vaccination with MVA/HIV induces differential ... - Retrovirology
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Vaccination with MVA/HIV induces differential ... - Retrovirology
Sep 13, 2012 - cessing genes (PSMA2, 3, 5), IL-6, and TLR-pathway genes (TLR1, LY96). Only 39 genes were up-regulated at. 72 hours post-vaccination.
Andersen-Nissen et al. Retrovirology 2012, 9(Suppl 2):O18 http://www.retrovirology.com/content/9/S2/O18
ORAL PRESENTATION
Open Access
Vaccination with MVA/HIV induces differential recruitment of monocyte subsets into the circulation and monocyte-specific transcriptional programs E Andersen-Nissen1*, DE Zak2, TR Hensley1, DJ Adams1, X Hu2, A Sato1, M Elizaga1, PA Goepfert3, HL Robinson4, A Aderem2, MJ McElrath1, the NIAID HIV Vaccine Trials Network1 From AIDS Vaccine 2012 Boston, MA, USA. 9-12 September 2012 Background Monocyte subpopulations are recruited from marrow to blood in response to infection and migrate into inflamed tissues to initiate adaptive immune responses. We sought to understand the effect of an MVA-vectored HIV vaccine on peripheral blood monocytes within the first week post-vaccination. Methods Volunteers were vaccinated with MVA/HIV62 gag/pol/ env (protocol HVTN 205/908); blood was collected prevaccination and 1, 3, and 7 days post-vaccination. Serum cytokine analysis was performed (n=13). Monocytes were phenotyped by flow cytometry (n=14) and microarray transcriptional profiling was performed on freshly-sorted monocytes (n=7). Results MVA/HIV induced serum elevations of the monocyte chemoattractant CCL2, and seven proinflammatory cytokines at 24 hours post-vaccination (p
