Validation Data set - PLOS

1 downloads 0 Views 19KB Size Report
Regulatory factor Nef - alpha(2)-beta(4)-alpha; 3 layers: alpha/beta/alpha ... HSP90 chaperone/DNA topoisomerase II/histidine kinase - 8-stranded mixed beta-.
Ligand 1 2 3 4 5 6 7

PPI CD81-LEL(HCV)-E2 Nef-SH3/Hck Nef-SH3/Hck Nef-SH3/Hck Nef-SH3/Hck Nef-SH3/Hck Nef-SH3/Hck

8

Hsp90/cdc37

9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26

Nef-SH3/Hck STAT3/STAT3 dimer STAT3/STAT3 dimer CD81-LEL(HCV)-E2 p53/MDM2 p53/MDM2 p53/MDM2 p53/MDM2 p53/MDM2 p53/MDM2 p53/MDM2 p53/MDM2 p53/MDM2 p53/MDM2 p53/MDM2 p53/MDM2 p53/MDM2 p53/MDM2

SCOP Fold Tetraspanin - 5 helices: irregular disulfide-linked array Regulatory factor Nef - alpha(2)-beta(4)-alpha; 3 layers: alpha/beta/alpha Regulatory factor Nef - alpha(2)-beta(4)-alpha; 3 layers: alpha/beta/alpha Regulatory factor Nef - alpha(2)-beta(4)-alpha; 3 layers: alpha/beta/alpha Regulatory factor Nef - alpha(2)-beta(4)-alpha; 3 layers: alpha/beta/alpha Regulatory factor Nef - alpha(2)-beta(4)-alpha; 3 layers: alpha/beta/alpha Regulatory factor Nef - alpha(2)-beta(4)-alpha; 3 layers: alpha/beta/alpha ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase - 8-stranded mixed betasheet; 2 layers: alpha/beta Regulatory factor Nef - alpha and beta protein STAT-like - 4 long helices; bundle, left-handed twist (coiled coil); right-handed superhelix STAT-like - 4 long helices; bundle, left-handed twist (coiled coil); right-handed superhelix Tetraspanin - 5 helices: irregular disulfide-linked array SWIB/MDM2 domain: core: 4 helices capped by two small 3-stranded beta-sheets SWIB/MDM2 domain: core: 4 helices capped by two small 3-stranded beta-sheets SWIB/MDM2 domain: core: 4 helices capped by two small 3-stranded beta-sheets SWIB/MDM2 domain: core: 4 helices capped by two small 3-stranded beta-sheets SWIB/MDM2 domain: core: 4 helices capped by two small 3-stranded beta-sheets SWIB/MDM2 domain: core: 4 helices capped by two small 3-stranded beta-sheets SWIB/MDM2 domain: core: 4 helices capped by two small 3-stranded beta-sheets SWIB/MDM2 domain: core: 4 helices capped by two small 3-stranded beta-sheets SWIB/MDM2 domain: core: 4 helices capped by two small 3-stranded beta-sheets SWIB/MDM2 domain: core: 4 helices capped by two small 3-stranded beta-sheets SWIB/MDM2 domain: core: 4 helices capped by two small 3-stranded beta-sheets SWIB/MDM2 domain: core: 4 helices capped by two small 3-stranded beta-sheets SWIB/MDM2 domain: core: 4 helices capped by two small 3-stranded beta-sheets SWIB/MDM2 domain: core: 4 helices capped by two small 3-stranded beta-sheets