Minor Illness or Major Disease? The Clinical Pharmacist in the Community, 4th
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Evaluate and manage risk factors. (weight, alcohol, diuretics, dietary purines).
TREATMENT OF GOUT. Treatment of acute gout flares. NSAIDs: given at regular
...
m u r i c AC I D
0.60 mmol/L
It should be noted that although effective treatment of gout can lead
New Zealand Rheumatology Association (NZRA),
to regression of tophi, management is far more difficult once tophi
endorsed by Medsafe.5
develop, due to the high total body urate load.
(full statement available at www.rheumatology.org.nz/colchicine.htm)
“Early treatment of gout, before onset of tophi and erosive disease, is recommended”
After the first 24 hours, the dose should be reduced to 0.5 mg one or two times daily, according to renal function. Prescribed in this way colchicine is safe and effective. The risk of diarrhoea and other toxic effects is minimised. Many patients report that one or two colchicine tablets taken within the first few hours of the onset of pain can avoid a major flare.
Hitting the target in gout: aim for a serum uric acid concentration of
