Jul 4, 1999 - Service, William S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace,. Madison, WI 53705. FAX: (608) 262-7644. E-mail: [email protected] ... Systemic fat mass (FM) and fat-free mass (FFM) were.
Visceral Obesity and Insulin Resistance Are Associated with Plasma Aldosterone Levels in Women Theodore L. Goodfriend, * David E. Kelley, f Bret H. Goodpaster, f and Stephen J. Winters? Abstract GOODFRIEND, THEODORE L., DAVID E. KELLEY, BRET H. GOODPASTER, AND STEPHEN J. WINTERS. Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women. Obes Res. 1999;7: 355-362. Objective: Both obesity and insulin resistance increase the risk of hypertension and other cardiovascular diseases, but the mechanisms linking these abnormalities are unknown. The current study was undertaken to examine the effects of obesity, fat distribution, and insulin resistance on plasma levels of aldosterone and other adrenal steroids that might contribute to sequelae of obesity. Research Methods and Procedures: Twenty-eight normotensive premenopausal women and 27 normotensive men with a wide range of body fat underwent measurements of visceral adipose tissue by CT scan, total fat mass by dual energy X-ray absorptiometry, blood pressure, insulin sensitivity, and plasma levels of three adrenal steroid hormones. Results: Plasma aldosterone in women correlated directly with visceral adipose tissue (r=O.66, p
