Vitamin D Deficiency and Gestational Diabetes Mellitus in Egyptian ...

Open Journal of Endocrine and Metabolic Diseases, 2016, 6, 109-119 Published Online February 2016 in SciRes. http://www.scirp.org/journal/ojemd http://dx.doi.org/10.4236/ojemd.2016.62015

Vitamin D Deficiency and Gestational Diabetes Mellitus in Egyptian Women Ghada M. El-Sagheer1, Asmaa Kasem1, Iglal M. Shawky2, Ahmed Abdel-Fadeel3 1

Diabetes & Endocrinology Unit, Internal Medicine Department, Minia University Hospital, Minia University, El-Minia, Egypt 2 Internal Medicine Department, Minia University Hospital, Minia University, El-Minia, Egypt 3 Clinical Pathology Department, Minia University Hospital, Minia University, El-Minia, Egypt Received 27 January 2016; accepted 26 February 2016; published 29 February 2016 Copyright © 2016 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/

Abstract Background: Although recent meta-analyses indicates a consistent significant inverse relation of serum 25 (OH) D and the prevalence of gestational diabetes mellitus (GDM), the mechanism is unclear and conflicting opinions continue to be reported. Objectives: The objectives are: 1) comparison of vitamin D status in diabetic and non-diabetic pregnant women; 2) trying to determine the level of vitamin D associated with GDM, and its sensitivity and specificity; 3) determination of the relation of hypovitaminosis D with insulin resistance. Subjects and Methods: One hundred consecutive pregnant women (