Grace A McComsey,4 Laura E Schanberg,5 for the APPLE investigators ..... conflicts of interest to disclose except that LES received consulting fees from.
Epidemiology and outcomes
Vitamin D deficiency is common and associated with increased C-reactive protein in children and young adults with lupus: an Atherosclerosis Prevention in Pediatric Lupus Erythematosus substudy Angela Byun Robinson,1 Vin Tangpricha,2 Eric Yow,3 Reut Gurion,1 Grace A McComsey,4 Laura E Schanberg,5 for the APPLE investigators
To cite: Robinson AB, Tangpricha V, Yow E, et al. Vitamin D deficiency is common and associated with increased C-reactive protein in children and young adults with lupus: an Atherosclerosis Prevention in Pediatric Lupus Erythematosus substudy. Lupus Science & Medicine 2014;1:e000011. doi:10.1136/lupus-2014000011
Received 9 January 2014 Revised 4 April 2014 Accepted 5 April 2014
For numbered affiliations see end of article. Correspondence to Dr Angela Byun Robinson; angela.robinson@ uhhospitals.org
ABSTRACT Objective: Epidemiological associations suggest vitamin D may play a role in inflammation and atherosclerosis. Using frozen serum and data from the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, we assessed associations between 25-hydroxyvitamin D [25(OH)D] and measures of systemic lupus erythematosus (SLE) disease activity and cardiovascular risk. Methods: Baseline APPLE serum samples were used to measure 25(OH)D levels. Logistic regression models for vitamin D deficiency [25(OH)D levels
