rickets have a lower vitamin D, Calcium and phosphorus levelsand higher alkaline ... Relation between Vitamin D Deficiency Rickets and Atopic Dermatitis.
American Journal of Medicine and Medical Sciences 2017, 7(2): 61-66 DOI: 10.5923/j.ajmms.20170702.04
Relation between Vitamin D Deficiency Rickets and Atopic Dermatitis Khaled Hassaan Awad1,*, Ismael Abd El Razek K. M. El-Lebedy1, Ahmad Saad Al Shemy1, Refaat Ragheb Mohamed2, Ali S. M.3 1
Pediatric Department, Al-Azhar University, Assiut, Egypt Dermatology Department, Al-Azhar University, Assiut, Egypt 3 Clinical Pathology Department, Al-Azhar University, Assiut, Egypt 2
Abstract As the pathogenesis of atopic dermatitis involves a complex interplay of epidermal barrier dysfunction and dysregulated immune response, and vitamin D is involved in both processes, it is reasonable to expect that vitamin D could be associated with atopic dermatitis' risk or severity. Such association is suggested by epidemiological and experimental data. The aim of this work is to study the association between atopic dermatitis and vitamin D deficiency rickets among children from 6 months up to two years. Patients and methods: this study was conducted on 40 children aged from 6-24 month, suffering from atopic dermatitis. They were subjected to full history taking, clinical examination including: assessment of growth and development, manifestations of atopic dermatitis, manifestations of rickets and examination of other systems. Serum vitamin D level, serum calcium level, Serum phosphorus level, Alkaline phosphatase enzyme level and Plain x-ray on long bones were done. Patients with atopic dermatitis were divided into 2 groups: (1) Group I: Atopic dermatitis with Rickets. (2) Group II: Atopic dermatitis without Rickets.- Children with dyslipidemia and or malnutrition were excluded from the study. Vitamin D therapy was given to group 1 for two months in addition to treatment of AD for both groups. Follow up of both groups for two months was done by clinical and laboratory assessment. Results: A statistically significant difference were found between group 1 and group 2 as regard the age (p=0.04), weight (p=0.04), body mass index (p=0.006), length (p=0.003), length percentile (p=0.02), anterior fontanel (p=0.004) and its size (p=0.32), family history of rickets (p=0.02), food containing vitamin D (p
