A. Basic Sleep Science VI. Learning, Memory, Cognition

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Jun 24, 2018 - VI. Learning, Memory, Cognition. 0244. A GOOD NIGHT SLEEP .... Sherman SM1, Kark SM1, Daley RT1, Hampton OL1, Payne JD2,.
A. Basic Sleep Science

VI. Learning, Memory, Cognition

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(immediate and morning). Similar to prior work in our lab, participants viewed static images, half of which contained a target signaling a potential threat. Subjects made a response (target present or absent), received feedback via a short video during training, and then were tested for two image types: repeated (identical from training to test) and generalized (same scene from training to test, but novel spatial viewpoint). During sleep after training, participants received 1.5 mA of closed-loop tACS (adapted to ongoing slow-wave oscillations) to F3 and F4 with returns on mastoids, or sham stimulation on different nights. Normalized spectral power changes in sleep EEG across stimulation events were correlated with performance changes over the night. Results: We observed not only a robust performance improvement but also a significant post-stimulation increase in power of slow-wave (0.5–1.5 Hz), delta (1.2–3 Hz), spindle (11–16 Hz), and gamma (30– 50 Hz) bands relative to pre-stimulation baseline (ps

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