Hezode, Jacob Lalezari, Franco Felizarta, Robert Reindollar, Stuart C. Gordon, Stephen. Pianko, Michael W. Fried, David E. Bernstein, Joel Gallant, Chih-Wei ...
(ascites, encephalopathy or esophageal varices), 2) a dominant biliary stricture requiring stent, dilation or drainage, 3) liver transplantation, 4) cholangiocarcinoma and/or 5) liverrelated death. Multivariate Cox regression was used to examine the association between IBD and the risk of progression to adverse liver outcomes, adjusting for age, gender, a small or large duct phenotype, overlap with autoimmune hepatitis (AIH), ursodiol use, as well as baseline MELD score and AST to Platelet Ratio Index (APRI). Results: 571/751 PSC patients (76%) had concomitant IBD (83% ulcerative colitis (UC), 17% Crohn disease (CD)). PSC without IBD was characterized by more females, a greater proportion of AIH overlap (51 vs. 28%), and a higher baseline MELD (4 vs. 0), APRI (1.57 vs. 0.68) and ALT (286 vs. 176), all p
