Association of primary sclerosing cholangitis with
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Association of primary sclerosing cholangitis with
Piecemeal necrosis was observed on liver histology in 66% of HLA-B8 positive and 50% of HLA-B8 negative patients. Low titres of serum autoantibodies were ...
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Gut, 1983, 24, 38-41
Association of primary sclerosing cholangitis with HLA-B8 R W CHAPMAN,* Z VARGHESE, R GAUL, G PATEL, N KOKINON, and SHEILA SHERLOCK
From the Departments of Medicine, Histopathology and Nephrology, Royal Free Hospital, Hampstead, London SUMMARY The frequency of HLA antigens was studied in 25 patients with primary sclerosing cholangitis and compared with a control group of 561 kidney donors. Fourteen patients also had ulcerative colitis. A significant increase in the frequency of HLA-B8 (60%) was found in the primary sclerosing cholangitis patients compared with controls (25%) (p
