A lack of consistent brain alterations in insomnia disorder: an activation likelihood estimation meta-analysis 1,2 Tahmasian ,
2 Noori ,
3 Samea ,
1 Zarei ,
4 Spiegelhalder ,
Masoud Khadijeh Fatemeh Mojtaba Kai 5,6 7,8 2 6,9 Simon B. Eickhoff , Eus van Someren , Habibolah Khazaie , Claudia R. Eickhoff
1 Institute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran., 2 Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran., 3 Institute for Cognitive and Brain Sciences, Shahid Beheshti University, Tehran, Iran., 4 Department of Psychiatry and Psychotherapy, Medical Centre – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany., 5 Institute of Systems Neuroscience, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany., 6 Institute of Neuroscience and Medicine (INM-1; INM-7), Research Center Jülich, Jülich, Germany., 7 Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam, Netherlands., 8 Departments of Psychiatry and Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Neuroscience Campus Amsterdam, VU University and Medical Center, Amsterdam, Netherlands., 9 Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
OHBM 2018,1438
1. Background:
3. Results:
Insomnia disorder is a prevalent sleep • Included studies consist of two PET studies, eight rsdisorder, which affects about 10% of fMRI studies, which applied various analysis methods, general population (1). However, its six task-fMRI studies including letter fluency, neural mechanisms are poorly category fluency, working memory, tower of London, understood. Recently, several and emotional tasks, as well as three voxel-based structural and functional neuroimaging morphometry studies. studies have been conducted in patients with insomnia disorder, but • Analyses across all experiments including both grey these studies have yielded diverse and matter atrophy and functional abnormalities revealed often conflicting findings (2). no significant convergence between different Here, we aimed to identify consistent neuroimaging studies performed in ID patients patterns of abnormal brain alterations compared to healthy controls (p-value for cFWE = in insomnia disorder by performing a 0.914). quantitative coordinate-based metaanalysis. • Repeating analysis with a more liberal statistical threshold (i.e. threshold-free enhancement (TFCE) demonstrated no significant findings as well (p = 2. Methods: 0.807). • Study selection: Following the preferred reporting for systematic reviews and meta-analyses statement (PRISMA), we searched PubMed database and used reference tracking and finally retrieved 19 eligible studies. • Data extraction: Peak coordinates (x,y,z) in Talairach or MNI stereotactic space extracted for conducting neuroimaging metaanalysis (3). We pooled data from the same samples to decrease within subjects effects (4).
A. Reported foci in patients with insomnia disorder compared to healthy subjects
4. Conclusion: B
Inconsistencies across the included studies might be related to heterogonous clinical populations that differed in several key aspects including diagnostic criteria, duration and severity of disease, age, and gender, and due to explorative nature of these studies in combination with small sample sizes, different experimental designs, and various preprocessing and statistical approaches. Future neuroimaging studies on insomnia disorder should include larger well-characterized samples, as well as standard neuroimaging and analysis protocols. C
B.AALE map of all structural and functional experiments
5. References:
C
• Separate analyses for different imaging modality or • Activation likelihood estimation increased versus decreased structural/functional (ALE): alterations were not possible because separate analyses Coordinate-based meta-analysis was should be performed only for those sets of direction performed using the revised version of and modality with at least 17 experiments available, ALE (3). given consideration on robustness and power (5).
1. Morin CM, et al. Nat Rev DisPrimers. 2015;1:15026. 2. Spiegelhalder K, et al. Curr Neurol Neurosci Rep. 2015;15(3):9. 3. Eickhoff SB, et al. Hum Brain Mapp. 2009;30(9):2907-26. 4.Turkeltaub PE, et al. Hum Brain Mapp. 2012;33(1):1-13. 5. Muller VI, et al. Neurosci Biobehav Rev. 2018;84:151-161.
E
Email:
[email protected]
