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Figure S2: Performance comparisons for FindPath, ExPA and efmtools for run time per output and memory use in function of size of input and size of output.
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Additional file 2 accompanying “The association of early combined lactate and glucose levels with subsequent renal and liver dysfunction and hospital mortality in critically ill patients” by Freire Jorge et al. Contents: For lactate and glucose quintiles: number of patients sFig5 APACHE-IV sFig6 DM incidence sFig7 steroid administration sFig8 insulin dose sFig9 max PT sFig10 max AST sFig11 max ALT sFig12 max AP sFig13 max GGT sFig14 glycemic variability sFig15 predicted mortality sFig16
Suppl. figure 5 – Number of patients 2000 1800 1600
number of patients
1400 1200 1000 800 600 >2.3
400
1.7-2.3
200 1.3-1.7 0
1.0-1.3 ≤7.0 7.0-7.6
≤1.0
7.6-8.2
8.2-9.0 mean glucose (mmol/L) quintiles
>9.0
mean lactate (mmol/L) quintiles
Legend for supplementary figure 5. Number of patients for combined lactate and glucose quintiles. Note that the majority of patients are in the diagonal between left-bottom to right-upper corner of the graph. The left-upper corner of the graph with lowest mean glucose and highest mean lactate represents 6% of our patient population.
Suppl. figure 6 – APACHE IV score 90
80
mean APACHE IV score
70 60 50 40 30 20
>2.3 1.7-2.3
10
1.3-1.7 0
1.0-1.3
≤7.0 7.0-7.6
≤1.0
7.6-8.2 8.2-9.0 mean glucose (mmol/L) quintiles
>9.0
mean lactate (mmol/L) quintiles
Legend for supplementary figure 6. Mean APACHE-IV score for combined lactate and glucose quintiles. Note that the highest quintile of lactate has overall the highest mean APACHE-IV score. Note also the U-curve that is observed in the highest lactate quintile across the glucose range. The group with the lowest glucose and highest lactate has the highest mean APACHE-IV score of all groups.
Legend for supplementary figure 7. Frequency of Diabetes mellitus for combined lactate and glucose quintiles. Note that the frequency of diabetes is the highest in highest glucose quintile. Also noticeable is a higher frequency of diabetes mellitus in the combined lowest glucose and highest lactate in comparison to the frequency observed in the second glucose quintile when combined with the highest lactate quintile.
Suppl. figure 8 – Steroid administration (%) 35%
steroids administered within 18h
30%
25%
20%
15%
10% >2.3 5%
1.7-2.3 1.3-1.7
0%
1.0-1.3 ≤7.0 7.0-7.6
≤1.0
7.6-8.2 8.2-9.0
mean glucose (mmol/L) quintiles
>9.0
mean lactate (mmol/L) quintiles
Legend for supplementary figure 8. Frequency of steroid administration for combined lactate and glucose quintiles. Note the U shape across the glycemic range for the highest lactate quintile. Also, the combined lowest glucose with the highest lactate quintiles has the highest frequency of steroid administration.
