Appendix A. Supplementary data Table A.1 Glaucoma

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... J. Hérault, P. Chauvel, Results of proton therapy of uveal melanomas treated in. Nice, Int. ..... transport, endocytosis, mechanotransduction, cell proliferation, [S103–S105] ... [S112]. CYP1B1. Cytochrome P450 monooxygenase located in ER, ...
Appendix A. Supplementary data Table A.1 Glaucoma following radiotherapy. Treatment Malignant disase External beam RT Single session 60 Co Uveal melanoma

Dose Mean, median (range), dose to/as

Dose fractions and dose rate

66 ± 11a, NA (NA) Gy

1–6 shots

a

Follow-up Mean, median (range)

Subjects Glaucoma post-RT Patients (eyes) Eye retained

24 ± 4a, NA (NA) mo

10 (NA)

a

Reference (year reported)

Enucleated

Onset post-RT

– 1 yr – NA NA NA NA NA

[S1] (1996)

18.7% Pt (NVG) 5 Pt (SG) 14% Pt (NVG) – 9 Pt (NVG) 20.83% (NVG) 19.72% (NVG) 8.06% (NVG)

– 1 Pt (NVG) 0 0 0 0 4 Pt (NVG) 7 Pt at 1 yr, 1 Pt at 2 yr 0 Pt at 3 yr (SG) 1–4 Pt (NVG) 2 Pt (SG) – 4 Pt (NVG) 6 Pt (NVG) 0 0 0

NA NA NA Mostly ! the first 3 yr NA NA NA NA

[S6] (2009) [S7] (1996) [S8] (2013)

0 – 17.5% Pt (SG)

– 11 Pt (SG)c 0

– 3–5 yr NA

[S11] (2014)

0 – 5 Pt (NVG) 20 Pt (SG)

– Med 20.8 (5.8–54) mo NA NA

[S13] (2008) [S14] (2016)

0 – 0 1 Pt (NVG) 21 Pt (NVG) 9% at 41.5 Gy, 48% at 52.1 Gy (NVG) 14 Pt (NVG) 0

Uveal melanoma Uveal melanoma Uveal melanoma Uveal melanoma Uveal melanoma Uveal melanoma

53 ± 11 , NA (NA) Gy 54 ± 6a, NA (NA) Gy NA, NA (45–80) Gy, tumor margin NA, NA (30–80) Gy, tumor margin NA, 31.4 (20–76.5) Gy, tumor margin 50, NA (NA) Gy, max dose

1–6 shots 1–6 shots Mean 2.7 (1–4) shots 1 Fr 1 Fr 1 Fr

16 ± 2 , NA (NA) mo 6 ± 3a, NA (NA) mo NA, NA (16–94) mo NA, NA (12–79) mo NA, 32 (10–74) mo NA, NA (1–3) yr

9 (NA) 17 (NA) 60 (NA) 64 (NA) 75 (NA) 100 (NA)

Uveal melanoma Posterior uveal melanoma Posterior uveal melanoma

NA, 35 (35–40b) Gy, tumor margin 70, NA (NA) Gy, tumor periphery 30, NA (NA) Gy, 50% isodose

1 Fr in 3–4 h 1 Fr 1 Fr

NA, 31.3 (17.6–60.6b) mo NA, 23.5 (18–36) mo NA, 40 (16–78) mo

78 (78) 14 (14) 50 (50)

Choroidal melanoma Ocular melanoma Ocular melanoma Ocular melanoma X-rays Posterior uveal melanoma

NA, 50 (40–80) Gy, tumor margin 50–70, NA (NA) Gy, 50% isodose 45, NA (NA) Gy, 50% isodose 35, NA (NA) Gy, 50% isodose

1 Fr 1 Fr 1 Fr 1 Fr

38, NA (6–81) mo NA, 63.5 mo (0.5–20 yr) NA, 63.5 mo (0.5–20 yr) NA, 63.5 mo (0.5–20 yr)

32 (NA) 24 (NA) 71 (NA) 62 (NA)

NA, 49 (37–52) Gy, max dose

1 Fr

NA, NA (!5) yr

96 (NA)

35, NA (NA) Gy [12 Gy, NA (NA) Gy, ON] [10 Gy, NA (NA) Gy, CB] NA, NA (18–22) Gy, 70% isodose 20.3, 20 (17–22) Gy

1 Fr

NA, NA (!2) yr

40 (NA)

1 Fr in 3 h 1 Fr in 3 h

13, NA (6–22) mo 29.6, 26.4 (5.9–84) mo

20 (NA) 217 (NA)

35 Gy, NA (NA) [NA, 45 (37–51) Gy, max dose] [NA, NA (

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