Jan 18, 2015 -
ejbps, 2015, Volume 2, Issue 1, 502-507.
Research Article
2349-8870 European Journal of of Biomedical and PharmaceuticalISSN Sciences EuropEan Journal Biomedical Volume: 2 AND Issue: 1 502-507 Pharmaceutical sciences
Obeagu et al.
Year: 2015
http://www.ejbps.com
ANTIOXIDANT-MEDIATED HEINZ BODIES LEVELS OF SICKLE ERYTHROCYTES UNDER DRUG - INDUCED OXIDATIVE STRESS 1
Aloh, G. S, 1
2*
Obeagu, Emmanuel Ifeanyi, 3Okoroiwu, I.L., 1Odo, Christian Emeka,
Odo Matthew Chibunna, 4Kanu,S.N, 5Elemchukwu, Q., 5Okpara,K.E., 6
1
Ugwu, Getrude Uzoma,
Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria. 2
Diagnostic Laboratory Unit,University Health Services, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria. 3
Department of Medical laboratory Science,Imo State University,Owerri,Nigeria. 4
Abia State University Teaching Hospital,Aba,Abia State,Nigeria. 5
Rivers State College of Health Technology,Port Harcourt.
Article Received on 27/12/2014
Article Revised on 18/01/2015
Article Accepted on 09/02/2015
*Correspondence for
ABSTRACT
Author
Heinz bodies formation was studied in control (non-HbSS) and sickle
Emmanuel Obeagu
(HbSS) erythrocytes in which oxidative stress was induced with
Diagnostic Laboratory Unit,University Health
acetylphenylhydrazine and subsequently treated separately with
Services, Michael Okpara
ascorbic acid and α-tocopherol. The control erythrocytes bore no Heinz
University of Agriculture,
bodies before APHZ treatment. On exposure to APHZ, their mean
Umudike, Abia State,
Heinz bodies level rose significantly (p
