Assessment of the Reproducibility of Postprocessing ... - CiteSeerX
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BACKGROUND AND PURPOSE: Commercially available software programs for the conver- sion of dynamic CT perfusion (CTP) source data into cerebral blood ...
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Assessment of the Reproducibility of Postprocessing ... - CiteSeerX
sion of dynamic CT perfusion (CTP) source data into cerebral blood volume (CBV), ... CONCLUSION: There is a high degree of correlation between parenchymal .... four decisions made by the analyst during the postprocessing of CTP data. 98.
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Assessment of the Reproducibility of Postprocessing Dynamic CT Perfusion Data David Fiorella, Joseph Heiserman, Erin Prenger, and Shahram Partovi
BACKGROUND AND PURPOSE: Commercially available software programs for the conversion of dynamic CT perfusion (CTP) source data into cerebral blood volume (CBV), cerebral blood flow (CBF), and mean transit time (MTT) maps require operators to subjectively define parameters that are used in subsequent postprocessing calculations. Our purpose was to define the variability of CBV, CBF, and MTT values derived from CTP maps generated from the same source data postprocessed by three different CT technologists (CTTs). METHODS: Raw data derived from dynamic CTP examinations performed in 20 subjects were postprocessed seven times by three experienced CTTs. Parenchymal regions of interest derived from each map (CBV, CBF, and MTT) were compared. The CBF maps generated by each technologist were also qualitatively assessed. Decisions made by each analyzer during postprocessing were assessed. RESULTS: The intraclass correlation coefficients were 0.73 (95% CI, 0.64 – 0.81), 0.87 (0.83– 0.91) and 0.89 (0.85– 0.93), for the CBV, CBF, and MTT parenchymal regions of interest, respectively. All individual correlation coefficients between data sets were significant to a P value
