Association between left atrial function using multimodality tissue ...
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Association between left atrial function using multimodality tissue ...
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Association between left atrial function using multimodality tissue tracking from cine MRI and myocardial scar in the multi-ethnic study of atherosclerosis (MESA) Masamichi Imai1*, Bharath Ambale Venkatesh1, Sanaz Samiei1, Mohammadali Habibi2, Anderson C Armstrong1, Susan Heckbert3, Sirisha Donekal1, David A Bluemke4, Colin O Wu4, Joao A Lima1 From 16th Annual SCMR Scientific Sessions San Francisco, CA, USA. 31 January - 3 February 2013 Background Left atrial (LA) function is strongly related to left ventricular (LV) filling pressures and has shown association to cardiovascular outcomes. A recently developed speckle tracking technique can assess LA deformation using CMR cine sequences. Myocardial scar assessed by late gadolinium enhancement (LGE-CMR) relates to cardiac remodeling, but its association to LA function is unknown. We explored the relationship of LA function with the amount of myocardial scar. Methods A total of 1666 participants from the MESA, age range 55-94 yrs, underwent LGE-CMR using 1.5T scanners at six field centers. Myocardial scar was visually detected, classified (ischemic/non-ischemic), and quantified using semi-automated methods in 136 participants. The amount of scar was quantified as the ratio of scar mass over total LV mass and values greater than 5% were defined as clinically significant. LA function was evaluated using multimodality tissue tracking (MTT) from SSFP 2- and 4-chamber long-axis cine CMR images in all participants with myocardial scar and in an age and gender matched control group of 136 participants without scar. LA function was assessed using peak longitudinal strain (Smax), diastolic longitudinal strain rate (SRdia), ejection fraction (LAEF), emptying fraction (LAEmF), and LA maximum volume (Vmax). Wilcoxon rank-sum test was used to evaluate differences between groups:
control, scar>5%, and scar5% groups while for LAEmF the difference was marginal (p=0.05). SRdia and LAEmF were significant when the scar>5% and scar
