Ototoxicity in Paediatrics. Author: Mukovhe Phanguphangu. Department of Audiology, West Rand District Health Services, Merafong, South Africa, Audiologist, ...
Hearing Loss Prevention in Cisplatin-Induced Ototoxicity in Paediatrics Author: Mukovhe Phanguphangu Department of Audiology, West Rand District Health Services, Merafong, South Africa, Audiologist, Researcher and Director, Williams Hearing and Balance Centre, Carletonville, South Africa, Department of Audiology, Pietersburg Provincial Academic Hospital, Polokwane, South Africa, Division of Communication Sciences and Disorders, Faculty of Health, University of Cape Town, Cape Town, South Africa
Background
Methods
The cochlea can protect itself from many toxins,
however, current research indicates that 75100%
of
paediatric
patients
treated
with
cisplatin acquire cisplatin-induced ototoxicity.
Results
To report on the current trends in an effort to
prevent ototoxicity To stimulate research in the area of preventative audiology regarding cisplatin induced ototoxicity.
Cisplatin, a chemotherapeutic drug, alters the endo-cochlear potential resulting in damage to the organ of corti, lateral wall and spiral ganglia. Consequently this causes a disruption in the firing of the hair cells in the cochlea, and thus result in a sensory hearing loss and tinnitus. Although monitoring, altering and changing dosage can be attempted, at times it is impractical to change the dose and as a result, a preventative agent would be more suited.
Results
Conclusions
3 oto-protectors are found in literature.
Sodium
Rybak et al (2010) adds that an ideal otoprotector should not: be toxic, be in high concentration to prevent damage to the cochlea and not interfere with the chemotherapeutic actions of cisplatin.
It’s a chain of events
`
Thio-sulphate,
Vitamin
E
and
Dexamethasone are somewhat effective in the prevention of cisplatin ototoxicity. Currently, however, there is no single ideal drug for preventing cisplatin induced ototoxicity More Clinical studies are needed in the field of
Although rigorous studies have been employed
preventative audiology for cisplatin induced
in this area of preventative audiology and
ototoxicity, particularly in paediatrics as the
medicine, currently there is no ideal oto-protector
effects of childhood hearing loss can be
in clinical practice.
detrimental to their development.
