Changes in platelet CD 62P expression and soluble P-selectin ...
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Changes in platelet CD 62P expression and soluble P-selectin ...
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Dymicka-Piekarska V, et al.
· Advances in Medical Sciences · Vol. 51 · 2006 ·
Changes in platelet CD 62P expression and soluble P-selectin concentration in surgically treated colorectal carcinoma Dymicka-Piekarska V 1*, Matowicka-Karna J1, Osada J 2, Kemona H1, Butkiewicz AM1 1
Department of Clinical Laboratory Diagnostics, Medical University of Białystok, Poland 2 Department of Hematology Diagnostics, Medical University of Białystok, Poland
Purpose: The aim of the present study was to assess the effect of tumor advancement and surgery treatment on P- selectin expression (CD 62P), level of sP-selectin and platelet count. Material and methods: The study involved 27 colorectal cancer patients (CRC). They were divided into two groups: group B1 – 18 patients (T2-3N0M0) and group B2 – 9 patients (T2-4N+M0). In CRC patients the blood was collected three times: 1) before surgery (A0), 2) 3 days after surgery and 3) 12 days after surgery. Results: The results obtained showed that CD 62P expression in CRC patients was twice higher (5.36%) than in control (2.58%) (p
