Ciproffoxacin Induces an Immunomodulatory Stress Response in ...
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Ciproffoxacin Induces an Immunomodulatory Stress Response in ...
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Ciprofloxacin Induces an Immunomodulatory Stress Response in Human T Lymphocytes KRISTIAN RIESBECK,* ARNE FORSGREN, AGNETHE HENRIKSSON, AND ANDERS BREDBERG Department of Medical Microbiology, Lund University, Malmo ¨ University Hospital, S-205 02 Malmo ¨, Sweden Received 9 February 1998/Returned for modification 13 May 1998/Accepted 3 June 1998
Exposure of cells to adverse environmental conditions invokes a genetically programmed series of events resulting in the induction of specific genes. The fluoroquinolone antibiotic ciprofloxacin has recently been reported to upregulate interleukin-2 (IL-2) gene induction. In the present investigation, the effect of ciprofloxacin at supratherapeutic concentrations on immediate-early (
