Jun 24, 2016 - Why Cloud computing for a bioreactor simulation? â Peak demands ... CAN CLOUD COMPUTING HELP? ... Real
CLOUD-BASED MULTIPHASE FLOW SIMULATION OF A BIOREACTOR PROJECT: CLOUDFLOW
23rd and 24th of June – Amsterdam
USE-CASE: BIOREACTOR Bioreactor is a device, which supports a biologically active environment It is used for the production of different organisms, which are used in pharmaceutical, chemical and food industries Pharma companies: Bayer, Pfizer, etc. Food & drink manufactures: Nestle, Paulaner Brewery, etc. Manufacturer of the bioreactors are equipment manufacturer: ZETA, VTU, VogelBusch Biopharma, Eppendorf etc.
Source: http://www.sanisure.com/
I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
ACTUAL PROBLEM AND WHY CAN CLOUD COMPUTING HELP? What is the problem and for whom? Long calculation time (about a week - caused by the need to run transient simulations up to 20 seconds) without a highly optimized workflow and huge computational resources Industry requires a calculation time not longer than one week These computational resources are often not affordable for SME Why simulation? Product improvement (e.g. higher cell density, number of viable cells etc.) Process understanding (e.g. scale up, new impeller design or number of impellers etc.) Improvement of process criteria (kLa, shear rate, homogenization etc.) Why Cloud computing for a bioreactor simulation? Peak demands can be covered
Huge number of CPUs are available on demand Possibility to perform DoE analysis (e.g. up to 25 parallel variants) Full cost control Already developed and proven workflow I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
EXPERIMENT CONSORTIUM SES-Tec OG, Austria
Leading partner and End-User Simulation technology consulter and service provider SME* AVL LIST GmbH, Austria Software vendor Large enterprise**
Arctur računalniški inženiring d.o.o., Slovenia HPC Provider SME* * fewer than 250 employees ** more than 250 employees
I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
EXPERIMENT DESIGN AND TECHNICAL APPROACH Fill level
Simulation model
Vessel
Rotor cell selection
Baffles Impeller
Stator cell selection Sparger
I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
CURRENT PROCESS WITHOUT USING CLOUD COMPUTATION
MISSING COMPUTATIONAL RESOURCES I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
EXPERIMENT DESIGN AND TECHNICAL APPROACH Implementation
WEB BROWSER AND CLOUDFLOW PORTAL
Solution Access to computational resources via Cloud - thus full cost control, shorter calculation time and affordable for SME Highly optimized workflow for this kind of application I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
3D RESULTS POSTPROCESSING IN CLOUD 2D and 3D data post-processing in Cloud Full integrated 2D/3D postprocessing application in Cloud No data transfer through network Simulation and residuals monitoring
I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
ECONOMIC IMPACT AND BUSINESS OPPORTUNITIES Cost saving
In house costs 45.000€ (12-16CPUs + License for a year)
120000
Utilization: about 80% per year
Cloud costs
100000
Cloud costs: 1,2 [€ / CPU h]
Costs [€]
In house costs
Real advantage of Cloud for an end-user
80000 60000
Huge number of variants in short calculation time, e.g. 25 variants in one week (no investment costs).
40000 20000 0 0
20
40
60
Nr. of Variants
80
100
Variant simulation (e.g. DoE) is not direct comparable with inhouse calculation, due to very high investment costs (e.g. 25*45.000€, practically not possible for SMEs)
I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
ECONOMIC IMPACT AND BUSINESS OPPORTUNITIES Time saving
Actual impact for SES-Tec In the next three years SES-Tec is planning to increase the actual turnover by 15% of the actual turnover only due to Cloud computing. SES-Tec We will contact potential customers (e.g. Vision Pharma (2016) and CPHI (2016)) and increase the market in the are of pharma and bio technology Furthermore, SES-Tec is planning to hire a new employee, which deals exclusively with cloud computation. I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
CONCLUSION AND FURTHER PLANS Cloud computing advantages No investment and service costs Available 24/7
Benefits from CloudFlow project Cloud computing knowledge and integration of a workflow Results of a DoE analysis in Cloud Experience and basis knowledge for other applications and integrations New services offer new application areas and new job positions
How I4MS helped SES-Tec With the help of I4MS it was possible to create a new tested application – in order to keep up also as an SME Provided a large network A SME is forced to economize differently as a large enterprise and therefore it is pretty tough to develop a cloud-based platform for a CFD simulation during the daily work
Dissemination and exploitation activities Contact with potential customers Usability test with SES-Tec customers (live demonstrations for potential new applications)
I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam
THANK YOU ANY QUESTIONS?