Sep 15, 2015 - Auburn, AL (US); Edward E. Morrison, Auburn, AL (US) ... (74) Attorney, Agent, or Firm - Haverstock & Owens LLP. (57). ABSTRACT.
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United States Patent
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Vodyanoy et al.
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COMPOSITIONS FORAND METHODS OF CONTROLLING OLFACTORY RESPONSES TOODORANTS
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Applicant: Auburn University, Auburn, AL (US)
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Inventors: Vitaly J. Vodyanoy, Auburn, AL (US); Nilmini Viswaprakash, Auburn, AL (US); Ludmila Petrovna Globa, Auburn, AL (US); Edward E. Morrison, Auburn, AL (US)
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Assignee: AUBURN UNIVERSITY, Auburn, AL (US)
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Notice:
Subject to any disclaimer, the term ofthis patent is extended or adjusted under 35 U.S.C. 154(b) by 0 days.
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Appl. No.: 14/029,678
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Filed:
Sep. 17, 2013 Prior Publication Data
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US 2014/0017338 Al
Jan. 16, 2014
Related U.S. Application Data (60)
Division of application No. 13/624,824, filed on Sep. 21, 2012, now Pat. No. 8,778,409, which is a division of application No. 12/079,661, filed on Mar. 27, 2008, now Pat. No. 8,273,381, which is a continuation-in-part of application No. 11/786,898, filed on Apr. 13, 2007, now abandoned.
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Provisional application No. 60/792,357, filed on Apr. 14, 2006.
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Int. Cl. A61K9/00 A61K 33130 A61K 311197 A61K 33132 A61M 15100 A61M31/00
(2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01)
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Patent No.: Date of Patent:
US 9,132,086 B2 Sep.15,2015
U.S. Cl. CPC ............. A61K 910043 (2013.01); A61K 311197 (2013.01); A61K 33130 (2013.01); A61K 33132 (2013.01); A61M 151009 (2013.01); A61M 31100 (2013.01) Field of Classification Search CPC ... A61K 9/0043; A61K 31/197; A61K 48/00; A61K 48/0008; A61M 15/009; C12N 15/87 See application file for complete search history.
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References Cited U.S. PATENT DOCUMENTS
2005/0112751 Al* 2006/0074025 Al*
512005 Fang et al ..................... 435/206 412006 Quay et al ....................... 514/12
OTHER PUBLICATIONS Wang, Guoshun, et al. "Increasing epithelial junction permeability enhances gene transfer to airway epithelia in vivo." American journal of respiratory cell and molecular biology 22.2 (2000): 129-138.* Merriam-Webster.com. 2014. http://merriam-webster.com/dictionary/instillation (accessed Mar. 2, 2014).*
* cited by examiner Primary Examiner - Bethany Barham Assistant Examiner - Peter Anthopolos (74) Attorney, Agent, or Firm - Haverstock & Owens LLP (57)
ABSTRACT
A composition, system and method for modifying an olfactory response to an odorant is disclosed. In some embodiments, the composition includes crystalline metal nanoparticles dispersed in an aqueous medium. The composition is applied to olfactory tissues using a suitable applicator or dispenser. The metal nanoparticles are believed to interact with a G-protein coupled to receptor located in the cilia to moderate (enhance or reduce) sensitivity or ability to smell particular odorants. In accordance with an embodiment of the invention, the composition includes one or more odorants. 13 Claims, 12 Drawing Sheets
