Correlation between genetic polymorphism of matrix ...
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Open Access Original Article
Correlation between genetic polymorphism of matrix metalloproteinase-9 in patients with coronary artery disease and cardiac remodeling Qibin Yu1, Hanmei Li2, Linlin Li3, Shaoye Wang4, Yongbo Wu5 ABSTRACT Objective: To explore the correlation between genetic polymorphism of matrix metalloproteinase-9 (MMP9) in patients with coronary artery disease (CAD) and cardiac remodeling. Methods: A total of 272 subjects who received coronary angiography in our hospital from July 2008 to September 2013 were selected, including 172 CAD patients (CAD group) and another 100 ones (control group). Both groups were subjected to MMP-9 and ultrasonic detections to determine vascular remodeling and atherosclerotic plaques. C1562G polymorphism of MMP-9 gene was detected, and correlation with vascular remodeling and atherosclerotic plaque was analyzed. Results: Serum MMP-9 level of CAD group (330.87±50.39 ng/ml) was significantly higher than that of control group (134.87±34.02 ng/ml) (P0.05 >0.05 >0.05
Pak J Med Sci 2015 Vol. 31 No. 3
www.pjms.com.pk 649
Qibin Yu et al.
Table-II: MMP-9 expression levels (ng/ml, x±s). Group
Case number (n)
MMP-9
CAD group
172
330.87±50.39
Control group
100
134.87±34.02
The numerical data were compared by Chisquare test, and subjected to nonparametric rank correlation test. P
