Derivation, validation, and evaluation of a new QRISK model to ...

Recommend Documents

An independent external validation and evaluation of QRISK ...

Wolfson College Annexe,. University of Oxford, Oxford. OX2 6UD. Correspondence to: G S Collins [email protected]. Cite this as: BMJ 2009;339:b2584.

Derivation and validation of a risk-factor model for ... - CiteSeerX

Jul 13, 2010 - mouth. The examiner was blinded to the risk-factor status. The ... entered into and analysed by the Statistical Package for Social. Sciences ..... to a social marketing strategy. ... delivered consistently through all available media.

Derivation and Validation of a Mathematical Model for Predicting the

influential variable for first year growth response was the natural log. (ln) of the ..... the fourth year explained 30% of the variability in the response, with a sD of ...

Derivation and Validation of a New Simulation ... - Semantic Scholar

E-mail: [email protected]. Hong Yang, M.Sc. (Corresponding Author). Graduate Research Assistant,. Department of Civil and Environmental Engineering,.

Derivation and validation of a formula to estimate ... - Oxford Journals

Apr 15, 2014 - Jack BW, Chetty VK, Anthony D et al. A reengineered hospital ... Silverstein MD, Qin H, Mercer SQ et al. Risk factors for 30-day hospital ...

Derivation and Validation of a Scoring System to ... - ScienceOpen

Dec 14, 2012 - infection (OR, 3.73, CI, 1.36â10.22, P=0.01); age $65 years (OR, 3.42, CI, 1.49â7.80, P=0.003); and Charlson Comorbidity. Index $4 (OR, 3.01, ...

Derivation and application of a new model for ... - Semantic Scholar

ment alternative [6] because many features of algae make them potentially good candidates for heavy metal removal [3,1,7]. From the viewpoint of application, ...

Validation of a New Biomechanical Model to Measure ...

Our model is based on previous work by Koo and Mak,21 in which the resisting ...... Winters JM, Stark L. Analysis of fundamental human move- ment patterns ...

Derivation and Validation of Two Decision

Oct 6, 2015 - Blunt Trauma Selective Chest CT Decision Instruments (NEXUS Chest CT) ...... links that can be accessed when viewing the PDF on a device.

Derivation and Validation of Multimarker ... - ATS Journals

Mar 15, 2014 - David Jim Â´enez1, Dita Kopecna1, Victor Tapson2, Beau Briese3, Donald ...... OM, Dolsma J, Eijsvogel M, Faber LM, Hofstee HM, Hovens MM,.

A Multi-Center Prospective Derivation and Validation of a ... - PLOS

Apr 23, 2015 - ... ONE policies on sharing data and materials. ... with severe CDI on univariate analysis (Table 1) were used to inform a .... When the prediction rule was applied to the validation cohort the correlation between the ... verity score

A New Derivation of the Clark's Model Using Entropy ... - arXiv

between the Clark model and the power law of urban area-population allometry. Batty and Kim ..... As Samuel Karlin (1983) pointed out: âThe purpose of models ...

Derivation and Validation of a Composite Index of ... - ATS Journals

Feb 19, 2009 - METHODS. The DOSE Index was derived from the Devon Primary Care COPD ..... One criticism that could be made concerns the way we went.

evaluation and validation of a new perceptual ... - Semantic Scholar

Route de Raoued 3.5 Km, CitÃ© El Ghazala, Ariana, 2083, TUNISIA anis ben ..... cessingâ Book, pp.230-245, edited by Springer Berlin, De- cember 2007. [5] J.H.L ...

Derivation and Validation of a Novel Right-Sided Heart ... - euromacs

Sep 5, 2017 - Kirklin JK, Naftel DC, Pagani FD, Kormos RL, Stevenson LW, Blume ED, ... Sun B, Tatooles AJ, Delgado RM 3rd, Long JW, Wozniak TC, Ghumman W, ... Kormos RL, Teuteberg JJ, Pagani FD, Russell SD, John R, Miller LW, ...

Derivation and Validation of a Binomial Sequential Decision ... - BioOne

Department of Plant, Soil and Entomological Sciences, University of Idaho, 875 Perimeter Drive, M.S. 2339, Moscow,. ID 83844-2339. J. Econ. Entomol. 106(6): ...

Derivation and validation of clinical phenotypes for COPD: a ...

We aimed to systematically review the literature for studies that had derived such ... validated statistical analyses, free of definitive pre-determined hypotheses, to derive phenotypes ...... Jo KW, Ra SW, Chae EJ, Seo JB, Kim NK, Lee JH, et al.

Derivation and validation of a preoperative risk ... - Semantic Scholar

Oct 30, 2017 - patients and could be used as a practical tool for care stratification and .... Firstly, only preoperative clinical and surgical routinely available ...

Derivation and Experimental Validation of a Power-Split ... - CiteSeerX

(e-CVT), derivation, hybrid electric vehicle (HEV), modeling, ... potential for better fuel economy and lower emissions without ..... Block diagram for the planetary gear sets system modeling. ..... Acceleration from 0 to 26.82 m/s (0 to 60 mi/h) and

Derivation and Validation of a GeriatricâSensitive ...

Nov 16, 2017 - The Revised Cardiac Risk Index (RCRI) and. Gupta MI and Cardiac Arrest (MICA) calculator are widely used indices to estimate perioperative ...

Derivation and validation of a clinical prediction rule ... - BioMedSearch

dependence and psychotropic medication) allowed us to classify patients on internal .... mentia drugs, antipsychotics, anti-Parkinson's drugs or anticonvulsants.

Derivation and Validation of a Binomial Sequential Decision Plan for

and valued at US$20â30 million (U.S. Department of. AgricultureâNational .... tices with two exceptions: there were no applications ..... ï¬eld staff that must balance sampling accuracy and ef- .... cards: a tool for Russian wheat aphid control.

Derivation and validation of a clinical prediction rule ... - BioMedSearch

Derivation and validation of a clinical prediction rule for delirium in patients admitted to a medical ward: an observational study. Juan Antonio Martinez,1 Ana ...

Derivation and Validation of a Prediction Score for ... - Diabetes Care

Salford, U.K.; and the 4Division of Medicine and Therapeutics, University of Dundee, Dundee, U.K.. Address correspondence and reprint requests to Dr. Peter T.

Derivation, validation, and evaluation of a new QRISK model to ...

Download PDF

2 downloads 95 Views 155KB Size Report

Comment

professor in medical statistics,1 John Robson, senior lecturer general practice,2 Peter Brindle, research and ... may not identify younger patients who, because of.

RESEARCH Derivation, validation, and evaluation of a new QRISK model to estimate lifetime risk of cardiovascular disease: cohort study using QResearch database Julia Hippisley-Cox, professor of clinical epidemiology and general practice,1 Carol Coupland, associate professor in medical statistics,1 John Robson, senior lecturer general practice,2 Peter Brindle, research and evaluation programme director3 1 Division of Primary Care, University Park, Nottingham NG2 7RD, UK 2 Centre for Health Sciences, Queen Mary’s School of Medicine and Dentistry, London E1 2AT, UK 3 Avon Primary Care Research Collaborative, NHS Bristol, South Plaza, Bristol BS1 3NX, UK Correspondence to: Julia HippisleyCox [email protected]

Cite this as: BMJ 2010;341:c6624 doi:10.1136/bmj.c6624

BMJ | ONLINE FIRST | bmj.com

ABSTRACT Objective To develop, validate, and evaluate a new QRISK model to estimate lifetime risk of cardiovascular disease. Design Prospective cohort study with routinely collected data from general practice. Cox proportional hazards models in the derivation cohort to derive risk equations accounting for competing risks. Measures of calibration and discrimination in the validation cohort. Setting 563 general practices in England and Wales contributing to the QResearch database. Subjects Patients aged 30–84 years who were free of cardiovascular disease and not taking statins between 1 January 1994 and 30 April 2010: 2 343 759 in the derivation dataset, and 1 267 159 in the validation dataset. Main outcomes measures Individualised estimate of lifetime risk of cardiovascular disease accounting for smoking status, ethnic group, systolic blood pressure, ratio of total cholesterol:high density lipoprotein cholesterol, body mass index, family history of coronary heart disease in first degree relative aged