Sep 20, 2013 - Adenocarcinoma arising from esophageal submucosal gland duct (ESGD) is a rare entity. We found several reports of esophageal adenomas ...
Surgical Pathology (Gastrointestinal, Genitourinary, Liver, Pancreas, Renal, Bone & Soft Tissue, Cardiovascular)/ Friday Session 3, September 20, 2013
184 Esophageal Submucosal Gland Duct Adenocarcinoma: A Case Series Maryam Tahmasbi, MD, Janese Trimaldi, MD, University of South Florida, Tampa; Domenico Coppola, MD, FASCP, Tampa, FL
Downloaded from http://ajcp.oxfordjournals.org/ by guest on January 18, 2016
Adenocarcinoma arising from esophageal submucosal gland duct (ESGD) is a rare entity. We found several reports of esophageal adenomas originating from these glands, but there is only one case report in the literature describing adencarcinoma arising from ESGD. Here, we report the histomorphological patterns of 10 cases of esophageal submucosal gland duct adenocarcinoma. In our collection we found 2 major histological patterns. One pattern was characterized by infiltrating dilated glands lined by flattened eosinophilic epithelium with dysplastic cells; occasionally displaying central necrosis. This pattern had a "swiss cheese"• appearance at low power. The second pattern was characterized by dilated glands lined by eosinophilic dysplastic cells exhibiting a "serrated lumen•." In some cases however both patterns were present simultaneously. In all cases the tumor glands were associated with underlying submucosal gland ducts. We believe that identification of this type of esophageal adenocarcinoma is important to avoid overestimation of the frequency of Barrett's-associated adenocarcinoma in the population. Additional studies are warranted to further characterized the immunohistochemical profile of this entity.
