1 Department of Urology, Qilu Hospital, Shandong University, Jinan, P.R. China; ... Biochemistry and Molecular Biology, Shandong University School of ...
Vol. 42 (2): 373-382, March - April, 2016
ORIGINAL ARTICLE
doi: 10.1590/S1677-5538.IBJU.2015.0025
Changes in mast cell infiltration: a possible mechanism in detrusor overactivity induced by visceral hypersensitivity _______________________________________________ Nian-zhao Zhang 1, Lin Ma 1, Chen Jun 1, Yan-xia Guo 2, Hui-qing Yuan 2 Department of Urology, Qilu Hospital, Shandong University, Jinan, P.R. China; 2 Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Shandong University, Jinan, P.R. China 1
ABSTRACT ARTICLE INFO ______________________________________________________________
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Objective: To establish the detrusor overactivity (DO) model induced by visceral hypersensitivity (VH) and investigate the relationship between mast cell (MC) infiltration and DO. Materials and Methods: Sixty rats are divided into 4 groups randomly: Group 1:Baseline group; Group 2: DO group; Group 3: CON group; Group 4: VH group. The colorectal distension (CRD) and abdominal withdral reflex (AWR) scores are performed to evaluate VH. The cystometric investigation and histological test of MC infiltration are assessed. Results: The threshold pressure of CRD in the VH group is significantly lower than that in the CON group (P
