A potential prognostic long non-coding RNA signature to predict ...
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OPEN
received: 07 April 2015 accepted: 15 October 2015 Published: 09 November 2015
A potential prognostic long noncoding RNA signature to predict metastasis-free survival of breast cancer patients Jie Sun1,*, Xihai Chen2,*, Zhenzhen Wang1,*, Maoni Guo1, Hongbo Shi1, Xiaojun Wang1, Liang Cheng1 & Meng Zhou1 Long non-coding RNAs (lncRNAs) have been implicated in a variety of biological processes, and dysregulated lncRNAs have demonstrated potential roles as biomarkers and therapeutic targets for cancer prognosis and treatment. In this study, by repurposing microarray probes, we analyzed lncRNA expression profiles of 916 breast cancer patients from the Gene Expression Omnibus (GEO). Nine lncRNAs were identified to be significantly associated with metastasis-free survival (MFS) in the training dataset of 254 patients using the Cox proportional hazards regression model. These nine lncRNAs were then combined to form a single prognostic signature for predicting metastatic risk in breast cancer patients that was able to classify patients in the training dataset into high- and low-risk subgroups with significantly different MFSs (median 2.4 years versus 3.0 years, log-rank test p
