May 10, 2012 - Miranda Kirby1,2, Andrew Wheatley1, Adam. Farag1, Alexei Ouriadov1, Giles E Santyr1,. David G McCormack3, and Grace Parraga1,2.
6/6/2015
ISMRM 20th Annual Meeting
Advances in Pulmonary Imaging Click on to view the abstract pdf. Click on presentation.
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Thursday 10 May 2012
Moderators: Room 219220
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Isabel Dregely, Scott K. Nagle
Pulmonary Parenchymal Blood Flow in Early Chronic Obstructive Pulmonary Disease (COPD): the MESA COPD Study permission withheld
Katja Hueper1,2, Jens VogelClaussen1,2, Megha Parikh3, John HM Austin3, David A Bluemke4, James Carr5, Thomas A Goldstein6, Antoinette S Gomes7, Eric A Hoffman8, Joao AC Lima1, Wendy Post1, Martin Prince3, Kiang Liu5, Jan Skrok1, Karol Watson7, Jie Zheng9, and Graham Barr3 1Johns Hopkins University, Baltimore, Maryland, United States, 2Hannover Medical School, Hannover, Germany, 3Columbia University Medical Center, New York, New York, United States, 4Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Maryland, United States, 5Northwestern University, Chicago, Illinois, United States, 6Stanford University, Stanford, California, United States, 7David Geffen UCLA School of Medicine, Los Angeles, California, United States, 8University of Iowa Carver College of Medicine, Iowa City, Iowa, United States, 9Washington University School of Medicine, St Louis, Missouri, United States Pulmonary vascular changes are known to occur in very severe chronic obstructive pulmonary disease (COPD). We hypothesized that pulmonary parenchymal blood flow and volume were decreased in mildmoderate COPD. Using pulmonary perfusion MRI we quantified perfusion parameters on a pixelby pixel basis in 100 patients with different severities of COPD and controls. Pulmonary parenchymal blood flow and volume were decreased in mild, moderate and severe COPD after adjustment for multiple parameters including the stroke volume, smoking status and packyears. These results support our hypothesis and demonstrate the value of pulmonary perfusion MRI for direct assessment of pulmonary vasculature in COPD. http://www.ismrm.org/12/Session62.htm
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13:42
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Automated assessment of regional lung perfusion in cystic fibrosis patients by using Fourier decomposition MRI Grzegorz Bauman1, Tobias Heimann2, Eva Fritzsching3, Wolfhard Semmler1, Michael Puderbach4,5, and Monika Eichinger4 1Dept. of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Dept. of Medical and Biological Informatics, German Cancer Research Center (DKFZ), Heidelberg, Germany, 3Division of Pediatric Pulmonology & Allergy and Cystic Fibrosis Center, University Hospital Heidelberg, Heidelberg, Germany, 4Dept. of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 5Clinics for Interventional and Diagnostic Radiology, Chest Clinics at the University of Heidelberg, Germany The aim of this work was to validate an automated scoring system of regional perfusion defects for data acquired by using a non contrastenhanced technique of Fourier decomposition 1H MRI (FDMRI) in a group of cystic fibrosis (CF) patients. This work proves that automated assessment of regional perfusion defects in CF patients with FDMRI is feasible and comparable to visual scoring. This diagnostic method could be well suited for reproducible and reader independent detection of early functional impairment and noninvasive monitoring of therapy response.
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Oxygenenhanced MRI vs. Quantitative CT vs. Perfusion SPECT/CT: Quantitative and Qualitative Capability to Predict Therapeutic Effect for Lung Volume Reduction Surgery Candidates
permission
withheld
Yoshiharu Ohno1,2, Mizuho Nishio1, Hisanobu Koyama1,2, Takeshi Yoshikawa1, Sumiaki Matsumoto1, Daisuke Takenaka1, Katsusuke Kyotani2, Nobukazu Aoyama2, Hideaki Kawamitsu2, Makoto Obara3, Marc van Cauteren4, and Kazuro Sugimura1 1Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan, 2Radiology, Kobe University Hospital, Kobe, Hyogo, Japan, 3Philips Electronics Japan, Tokyo, Japan, 4Philips Healthcare Asia Pacific, Tokyo, Japan http://www.ismrm.org/12/Session62.htm
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O2enhanced MRI can assess regional ventilation and alveolocapillary gas transfer of molecular oxygen. However, none of these studies have examined the quantitative and qualitative capabilities of O2enhanced MRI for evaluation of candidates for lung volume reduction surgery (LVRS), and compared with that of evaluation by means of thinsection MDCT and perfusion SPECT/CT. The purpose of the study was thus to prospectively and directly compare the quantitative and qualitative capabilities of O2enhanced MRI, thinsection MDCT and perfusion SPECT/CT to predict therapeutic outcomes for LVRS candidates. 14:06
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Free Breathing Ultra Echo Time Lung Imaging with Variable Density 3D Radial Sampling Kevin Michael Johnson1, Scott K Nagle1,2, and Sean B Fain1,2 1Medical Physics, University of Wisconsin Madsion, Madison, WI, United States, 2Radiology, University of Wisconsin Madison, Madison, WI, United States Detailed lung structure is poorly visualized with conventional MRI due to low tissue density and rapid signal decay. Ultrashort echo time (UTE) imaging has long held promise to dramatically enhance signal from short T2/T2* species. Due to a long T1 and low tissue density, 3D UTE lung imaging remains extraordinarily sensitive to artifacts from Gibbs ringing, physiological motion, eddy current induced errors, and low signal to noise ratio (SNR). In this work, we develop a robust technique for freebreathing, highresolution 3D UTE imaging that aims to mitigate sources of diagnostically obscuring artifacts.
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Lightingup the lungs: an UTE MRI investigation of the parenchyma signal enhancement due to intratracheal administration of an innovative Sibased Gd contrast agent Andrea Bianchi1, François Lux2, Gael Dournes1, Olivier Tillement2, and Yannick Crémillieux1 1Center of CardioThoracic Research, University of Bordeaux Segalen, Bordeaux, France, 2Laboratoire de PhysicoChimie des Matériaux Luminescents, Université Lyon 1, Lyon, France
http://www.ismrm.org/12/Session62.htm
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In this study we present the MRI investigation of the T1enhancement of the lung signal due to the intratracheal administration of different concentrations of a silicabased gadolinium contrast agent, characterized by ultrasmall nanoparticles and high relaxivity. The MRI investigation of the temporal evolution of the signal enhancement is also presented to get an estimate of the contrast agent residence time in the lungs. Notably high signal enhancements (> 200% for a 50 mM solution) with relatively small instilled volumes (50 µl) have been measured thanks to the high S/N and the negligibility of motion artifacts, typical of the UTE sequence. 14:30
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Hyperpolarized Xe129 CSI of the Human Lung: Preliminary Results from Healthy, SecondHand Smoker and CysticFibrosis Subjects Sara Reis1,2, Kai Ruppert1, Talissa Altes1, John Mugler III1, Iulian Ruset3, Wilson Miller1, William Hersman3, and Jaime Mata1 1Radiology & Medical Imaging, University of Virginia, Charlottesville, Virginia, United States, 2IBEB FCUL, Universidade de Lisboa, Lisboa, Portugal,3Xemed, New Hampshire, United States From the Xe129 CSI data, we directly calculate imagemaps reflecting the amount of Xe129 in the airspaces (gas), and dissolved in the lung tissue (parenchyma/plasma), red bloodcells (RBC), and other compartments, thus obtaining detailed spatial information regarding how Xe129 is distributed in these multiple compartments and providing regional information about lung physiology. Here we demonstrate that Xe129 3DCSI technique can be a very useful and unique clinical tool for lung disease, capable to obtain more regional information than current clinical tools.
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Hyperpolarized Helium3 and Xenon129 Magnetic Resonance Imaging of Elderly Neversmokers and Exsmokers with Chronic Obstructive Pulmonary Disease
Miranda Kirby1,2, Andrew Wheatley1, Adam Farag1, Alexei Ouriadov1, Giles E Santyr1, David G McCormack3, and Grace Parraga1,2 1Imaging Research Laboratories, Robarts Research Institute, London, ON, http://www.ismrm.org/12/Session62.htm
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Canada, 2Medical Biophysics, The University of Western Ontario, London, Ontario, Canada, 3Division of Respirology, Department of Medicine, The University of Western Ontario The objective of this study was to compare hyperpolarized helium3 (3He) and hyperpolarized xenon129 (129Xe) magnetic resonance imaging (MRI) in chronic obstructive pulmonary disease (COPD) exsmokers and agematched neversmokers. 3He and 129Xe images were segmented using image segmentation/registration software. In 10 COPD subjects and 8 neversmokers, 129Xe ventilation defect percent (VDP) was statistically significantly higher than 3He VDP (p