Assessment of Quality of Life Using Three Activity Questionnaires in ...
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Hellenic J Cardiol 2009; 50: 269-274
Original Research Assessment of Quality of Life Using Three Activity Questionnaires in Heart Failure Patients After Monthly, Intermittent Administration of Levosimendan During a Six-Month Period EVANGELIA F. PAPADOPOULOU, SOPHIE I. MAVROGENI, ATHANASIOS DRITSAS, DENNIS V. COKKINOS 1st Cardiology Department, Onassis Cardiac Surgery Centre, Athens, Greece
Key words: Specific Activity Questionnaire (SAQ), Left Ventricular Dysfunction 36 (LVD 36), Minnesota Living With Heart Failure questionnaire (LIhFE), heart failure.
Manuscript received: June 20, 2008; Accepted: March 12, 2009.
Introduction: Quality of life (QOL) in heart failure patients is severely compromised by the symptoms of the disease. Acute administration of levosimendan improves patients’ symptoms for intervals of 7-10 days. The aim of this study was to assess the QOL in heart failure patients, after monthly, intermittent administration of levosimendan for a 6-month period, using 3 activity questionnaires: Specific Activity Questionnaire (SAQ), Left Ventricular Dysfunction 36 (LVD 36), and Minnesota Living with Heart Failure Questionnaire (LIhFE). Methods: We prospectively studied 20 patients, age 61.0 ± 15.7 years (mean ± SD) with heart failure (NYHA III and IV). Levosimendan was administered intravenously for 24 hours (dose 0.1 mg/kg/min), 1 day every month for a 6-month period. Patients were asked to answer the questions of the 3 activity questionnaires SAQ, LVD36 and LIhFE before and after the end of the 6-month period. Results: For the LIhFE (the best score is 0 and the worst 105) before levosimendan the score was 35.4 ± 18.6 and after 6 months 22.2 ± 13.0 (p