Volume 8, Issue 4, 2018, 3364 - 3367
ISSN 2069-5837
Oluyomi Stephen Adeyemi, Isaac Oluwafemi Olajide, Anne Adebukola Adeyanju, Oluwakemi Josephine Awakan, David Adeiza Otohinoyi
Biointerface Research in Applied Chemistry www.BiointerfaceResearch.com
Original Research Article
Open Access Journal Received: 20.07.2018 / Revised: 08.08.2018/ Accepted: 12.08.2018 / Published on-line: 15.08.2018
Modulation of rat plasma kynurenine level by platinum nanoparticles and likely association with oxidative stress Oluyomi Stephen Adeyemi 1,*, Isaac Oluwafemi Olajide 1 , Anne Adebukola Adeyanju 2, Oluwakemi Josephine Awakan 1, David Adeiza Otohinoyi 3 1
Medicinal Biochemistry, Nanomedicine and Toxicology Laboratory, Department of Biological Sciences, Landmark University, PMB 1001, Km 4, Ipetu Road, OmuAran-251101, Nigeria 2 Department of Biological Sciences, McPherson University, Seriki-Sotayo, Ogun State, Nigeria 3 School of Medicine, All Saints University, Hillsborough Street, Roseau, Commonwealth of Dominica *corresponding author e-mail address:
[email protected]
ABSTRACT In this study, we investigated whether oxidative stress contributes to activation of kynurenine pathway by platinum nanoparticles (PtNPs). Thirty male Wistar rats with an average weight between 126 – 130 g were randomly assigned into six groups. The negative control group was orally administered distilled water while the other treatment groups respectively received oral administration of either PtNPs (25 and 50 mg/kg bw) singly or in combination with ascorbic acid (100 mg/kg bw). Results revealed that oral administration of PtNPs did not cause lipid peroxidation in rat brain and plasma relative to negative control. In contrast, PtNPs elevated protein carbonyl levels in rat plasma relative to negative control. In the meantime, the level of reduced glutathione (GSH) in rat tissues was maintained when compared with negative control and PtNPs alone. However, plasma GSH was significantly (p
