Wiley (2005). A well -illustrated book presenting enzyme kinetics/mechanics and
metabolism in an ... It forms a useful textbook for systems biologists who build ...
Assumes some prior knowledge of basic calculus. ... McGraw-Hill Medical (2007).
BOOK LIST
Below are some books and free-content weblinks that may be useful in terms of background study for the BHF Centre training and research programmes. Many journals offer full electronic access to articles if you go through the Imperial College Library homepage and the “electronic journals” link: http://www3.imperial.ac.uk/library/digitallibrary/electronicjournals
BIOCHEMISTRY AND BIOPHYSICS •
“Biochemistry” D Voet and JG Voet. Wiley (2005) A well -illustrated book presenting enzyme kinetics/mechanics and metabolism in an accessible format. It forms a useful textbook for systems biologists who build metabolic and/or mechanistic models.
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“Lehninger: Principles of Biochemistry” DL Nelson and MM Cox. WH Freeman (2005) The classic biochemistry text, and an alternative to Voet & Voet, but with less detail.
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“Biological Physics: Energy, Information, Life”. P. Nelson. WH Freeman (2003). A good introduction to the application of physics to biological problems, aimed at both physicists and biologists. Assumes some prior knowledge of basic calculus.
MOLECULAR AND CELLULAR BIOLOGY •
“Molecular Cell Biology” by Lodish et al, Freeman & Co. http://bcs.whfreeman.com/lodish5e/default.asp Lots of free content for students. The “bible” for all matters to do with DNA and gene expression. signalling and cell structural biology.
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You may also find “Genes IX” by Ben Lewin useful. http://biology.jbpub.com/book/genes/
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“Heart Development” (Edited by RP Harvey and N Rosenthal), Academic Press (1999). The best and most comprehensive resource for heart development. A fully revised version will be launched in 2009.
CARDIOVASCULAR CELL AND ORGAN PHYSIOLOGY •
“Introduction to Cardiovascular Physiology”. JR Levick (3rd Edition). Hodder Arnold (2000)
BIOMECHANICS AND BLOOD FLOW •
“Biomechanics: From Cells to Organisms”. CR Ethier and CA Simmons. Cambridge University Press. (2007).
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“The Mechanics of the Circulation”. CG Caro, TJ Pedley, RA Schroter and A Seed. Oxford University Press.
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“McDonald's Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles”. WW Nichols and MF O’Rourke. Hodder Arnold Publications
CARDIOVASCULAR MEDICINE •
“Braunwald’s Heart Disease”, (8th Edition). Edited by P Libby, R Bonow, D Zipes and D Mann. Elsevier. (2007) The authoritative clinical text aimed at the practicing cardiologist, Braunwald brings together all of the latest developments revolutionizing cardiovascular clinical practice, from molecular biology and genetics to advances in imaging, interventional procedures, and medications. Available as single or two-volume editions. The multimedia e-editions of both include not only the print version, but also access to the complete contents online, fully searchable, and regularly updated.
The following alternative texts are available through Imperial College Libraries as an electronic version:
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“Hurst’s The Heart” (12th Edition) Edited by V Fuster, RA O'Rourke, R Walsh and P Poole-Wilson. McGraw-Hill Medical (2007) http://online.statref.com/TOC.aspx?grpalias=ICL&FxId=67
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“Textbook of Cardiovascular Medicine” Edited by EJ Topol. Lippincott Williams & Wilkins (2007). http://ovidsp.ovid.com/ovidweb.cgi?T=JS&MODE=ovid&NEWS=n&PAGE=booktext&D =books&SC=00140011
PRACTICAL LAB MANUALS •
“Current Protocols in Molecular Biology” Edited by FA Ausubel, R Brent, RE Kingston, DD Moore, JG Seidman, JASmith and K Struhl. Greene Publishing and Wiley-Interscience. The international standard by which all laboratory manuals are judged, this comprehensive three-volume set of laboratory protocols in ring binder format covers basic and advanced molecular biology techniques, with easy-to-follow protocols throughout. The concepts behind each protocol and potential problems are discussed, and alternative protocols presented. Updated quarterly with new and/or revised chapter sections. Can be accessed online through the following link: http://www3.interscience.wiley.com/cgi-bin/mrwhome/104554809/HOME
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“Current Protocols in Protein Science” Wiley Quarterly Serials
MATHEMATICS AND STATISTICS •
“Mathematical Models in Biology” L Edelstein-Keshet. Cambridge University Press, (2005) This book features easily accessible and engaging biological examples: a good choice for those new to modelling. The text covers difference equations, ordinary differential equations, partial differential equations, kinetic laws and basic dynamical systems.
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“Handbook of Parametric and Nonparametric Statistical Procedures” DJ Sheshkin. Chapman &Hall/CRC (2004) Described as a solid reference for statistical analysis, this text provides practical advice on selecting a statistical test appropriate to a particular type of data and hypothesis. More than 130 statistical procedures are described.
SYSTEMS BIOLOGY The following Nature Journals link has a thorough list of new and older texts that are useful to the systems biologist, covering basics in applied mathematics, molecular and protein biology, biochemistry and systems biology theory and practise. Some of these suggested texts are summarised in the following section. http://www.nature.com/focus/systemsbiologyuserguide/appendices/textbooks.html
Systems biology — general textbooks •
“An Introduction to Systems Biology”. U Alon. Chapman & Hall/CRC (2006) This book is an excellent introduction to systems biology, revealing the mathematical and biological underpinnings of cell-signalling circuits.
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“System Modeling in Cellular Biology” Z Szallasi, J Stelling, and V Periwal. MIT Press (2006). A collection of review articles that address crucial issues that systems biologists come up against, for example, data acquisition and handling, modelling techniques, computational constraints and simulation.
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“Stochastic Modeling for Systems Biology” DJ Wilkinson. Chapman & Hall/CRC (2006). This book ranges from stochastic modelling and simulation to parameter estimation. Assumes prior understanding of some calculus and algebra.
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“Live Cell Imaging: A Laboratory Manual “R. D. Goldman and DL Spector. Cold Spring Harbor Laboratory Press (2005). A useful text for those using imaging to generate data for systems analysis, it discusses methodologies methodologies and applications in depth.
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“The Visual Display of Quantitative information” ER Tufte. Graphics Press (2001) One of a series of three well-written books by Tufte, this explains best practices for the graphical representation of multivariate data.
Applied Mathematics for Systems Biologists •
“Multivariate Analysis of Quality, An Introduction” H Martens and M Martens. Wiley (2000). Tools for analysis and model-building from multivariate data sets are described. Although based in and intended for an industry audience. Martens’ book is readily accessible to life scientists who do not have formal training in statistics or linear algebra.
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“Applied Regression Analysis and Multivariable Methods” DG Kleinbaum, LL Kupper, KE Muller and A Nizam. Duxbury Press (1997). This book gives clear examples of many linear regression methods and related diagnostics. Like the Martens’ book, this is readable and accessible to life scientists and requires minimal mathematical background.
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“Nonlinear Regression”. GA Seber and CJ Wild. Wiley-Interscience (2004). More mathematical than Kleinbaum, but absolutely essential for the systems biologist as most problems are nonlinear.
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“Introduction to Algorithms”. T Cormen, C Leiserson, R Rivest and C Stein. MIT Press (2001) Introduction to Algorithms is the classic algorithms text for computer-science students. Both readable and rich in concepts, it offers essential concepts in programming for systems biologists who need to write their own programs, including: functions, recursion, trees, sorting, data structures and graphs.
