DESIGN/METHODS: This prospective and retrospective study included 51 patients with 27 Isolated Growth. Hormone Deficiency(IGHD) & 24 Multiple Pituitary ...
[2906.67] Clinical, Biochemical and Neuro-Radiological Correlates in Children With Growth Hormone Deficiency Shilpa Mehta, Meena Desai, Shilpa Mithbawkar. Pediatrics, Brookdale University Hospital and Medical Centre, New York, NY; Pediatrics, Sir H.N. Hospital and Research Centre, Mumbai, Maharashtra, India.
OBJECTIVE: Documentation of Magnetic Resonance Imaging (MRI) anomalies of hypothalamic-pituitary region in patients with Growth Hormone (GH) Deficiency and study its relationship with clinical, biochemical and hormonal parameters. DESIGN/METHODS: This prospective and retrospective study included 51 patients with 27 Isolated Growth Hormone Deficiency(IGHD) & 24 Multiple Pituitary Hormone Deficiency (MPHD).Morphological features of Anterior Pituitary, presence and location of Posterior Pituitary and completeness of pituitary stalk were studied and correlated with clinical,biochemical and hormonal parameters. RESULTS: The results of MRI findings were: incidence of anterior pituitary hypoplasia (APH) was 80% (74% IGHD vs 87% MPHD), ectopic/invisible posterior pituitary (EPP) was 33% (25% IGHD vs 41% MPHD), interrupted/invisible stalk was 30% (25% IGHD vs 33% MPHD), Classic triad (APH, EPP and interrupted stalk) was 20% (22% IGHD vs17% MPHD), Empty Sella was 25% (22% IGHD vs 29% MPHD) and normal Pituitary was 26% (22% IGHD vs 4% MPHD). MPHD patients showed lower mean sagittal (2.97 ± 1.08 Vs 1.82 ± 1.33, p
