Combined aerobic and resistance training improves bone health of female cancer survivors Hawley C. Almstedt, Silvie Grote, Joshua R. Korte, Stephanie Perez Beaudion, Todd C. Shoepe, Sarah Strand, Heather P. Tarleton PII: DOI: Reference:
S2352-1872(16)30038-9 doi: 10.1016/j.bonr.2016.09.003 BONR 80
To appear in:
Bone Reports
Received date: Revised date: Accepted date:
22 July 2016 7 September 2016 20 September 2016
Please cite this article as: Hawley C. Almstedt, Silvie Grote, Joshua R. Korte, Stephanie Perez Beaudion, Todd C. Shoepe, Sarah Strand, Heather P. Tarleton, Combined aerobic and resistance training improves bone health of female cancer survivors, Bone Reports (2016), doi: 10.1016/j.bonr.2016.09.003
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Title: Combined Aerobic and Resistance Training Improves Bone Health of Female Cancer Survivors
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Running Title: CART improves bone health of cancer survivors
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Authors: Hawley C. Almstedt1, Silvie Grote1, 2, Joshua R. Korte1, Stephanie Perez Beaudion1, Todd C. Shoepe1, Sarah Strand1, & Heather P. Tarleton1 1
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Department of Health and Human Sciences, Loyola Marymount University, Los Angeles, CA, USA 2
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Center for Nutrition, Healthy Lifestyle, and Disease Prevention, School of Public Health, Loma Linda University, Loma Linda, CA, USA
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Corresponding Author Contact Information: Hawley C. Almstedt, Ph.D., R.D.N. Associate Professor Department of Health and Human Sciences 1 LMU Drive, MS 8888 Loyola Marymount University Los Angeles, CA 90045 USA Office: 310-338-1925 Fax: 310-338-5317
[email protected]
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Abstract
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Introduction: Cancer pathogenesis and resulting treatment may lead to bone loss and poor skeletal health in survivorship. The purpose of this investigation was to evaluate the influence of
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26 weeks of combined aerobic and resistance-training (CART) exercise on bone mineral density
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(BMD) in a multi-racial sample of female cancer survivors. Methods: Twenty-six female cancer survivors volunteered to undergo CART for 1 hour/day, 3 days/week, for 26 weeks. The
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Improving Physical Activity After Cancer Treatment (IMPAACT) Program involves supervised
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group exercise sessions including 20 minutes of cardiorespiratory training, 25 minutes of circuitstyle resistance-training, and 15 minutes of abdominal exercises and stretching. BMD at the
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spine, hip, and whole body was assessed using dual-energy x-ray absorptiometry (DXA) before
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and after the intervention. Serum markers of bone metabolism (procollagen-type I N-terminal
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propeptide, P1NP, and C-terminal telopeptides, CTX) were measured at baseline, 13 weeks, and at study completion. Results: Eighteen participants, with the average age of 63.0±10.3 years, completed the program. Mean duration since completion of cancer treatment was 6.2±10.6 years. Paired t-tests revealed significant improvements in BMD of the spine (0.971±0.218 g/cm2 vs. 0.995±0.218 g/cm2, p=0.012), hip (0.860±0.184 g/cm2 vs. 0.875±0.191 g/cm2, p=0.048), and whole body (1.002±0.153 g/cm2 vs. 1.022±0.159 g/cm2, p=0.002). P1NP declined 22% at 13 weeks and 28% at 26 weeks in comparison to baseline (p
