Comparison of safety and immunogenicity of purified chick embryo cell
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Comparison of safety and immunogenicity of purified chick embryo cell
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Comparison of safety and immunogenicity of purified chick embryo cell vaccine using Zagreb and Essen regimens in patients with category II exposure in China Wuhan Centers for Disease Prevention and Control; Wuhan, PR China These authors contributed equally to this work.
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Keywords: rabies, vaccine, PCECV, post-exposure prophylaxis, Zagreb regimen, Essen regimen, safety, immunogenicity Abbreviations: PCECV, purified chick embryo cell vaccine; RFFIT, rapid fluorescent focus inhibition test; WHO, World Health Organization
The aim was to compare the safety and immunogenicity of purified chick embryo cell vaccine (PCECV) with Zagreb 2-1-1 and Essen 1-1-1-1-1 regimens in patients with WHO category II exposure in China. Side effects including systemic and local symptoms were recorded for all patients during vaccination with purified chick embryo cell vaccine (PCECV) under Zagreb 2-1-1 or Essen 1-1-1-1-1 regimens, and the rabies neutralization antibody titers in patients’ serum at days 0, 7, 14, 45, 365 post-immunization were measured to determine the immunogenicity. Fever and pain were the most common events for systemic and local symptoms respectively, and most side effects (86.78%, 105/121) occurred after the first dose of vaccination. Safety analysis showed differences in side effects in
