Contents Volume 53, Number 5 EDITORIALS Homocysteine and Cardiovascular Risk: Considering the Evidence in the Context of Study Design, Folate Fortification, and Statistical Power. P.M. Ueland and R. Clarke
807
Insulin Immunoassays: Fast Approaching 50 Years of Existence and Still Calling for Standardization. R. Sapin
810
Comparison of the Diagnostic Accuracy of Brain Natriuretic Peptide (BNP) and the N-Terminal Part of the Propeptide of BNP Immunoassays in Chronic and Acute Heart Failure: A Systematic Review. A. Clerico, M. Fontana, L. Zyw, C. Passino, and M. Emdin
813
REVIEW
ARTICLES MOLECULAR DIAGNOSTICS
AND
GENETICS
Validation of a CYP2D6 Genotyping Panel on the NanoChip Molecular Biology Workstation. H.-K. Lee, L.D. Lewis, G.J. Tsongalis, B.C. Schur, P.J. Jannetto, S.H. Wong, and K.-T.J. Yeo
823
SPP1 Promoter Polymorphisms: Identification of the First Modifier Gene for Pseudoxanthoma Elasticum. D. Hendig, M. Arndt, C. Szliska, K. Kleesiek, and C. Go¨tting
829
Generation of Human Monoclonal Allergen-Specific IgE and IgG Antibodies from Synthetic Antibody Libraries. I. Braren, S. Blank, H. Seismann, S. Deckers, M. Ollert, T. Grunwald, and E. Spillner
837
Homocysteine, 5,10-Methylenetetrahydrofolate Reductase 677C>T Polymorphism, Nutrient Intake, and Incident Cardiovascular Disease in 24 968 Initially Healthy Women. R.Y.L. Zee, S. Mora, S. Cheng, H.A. Erlich, K. Lindpaintner, N. Rifai, J.E. Buring, and P.M Ridker
845
PROTEOMICS
AND
PROTEIN MARKERS
Reproducibility in Protein Profiling by MALDI-TOF Mass Spectrometry. J. Albrethsen
852
Diagnostic Accuracy of ELISA and xMAP Technology for Analysis of Amyloid 42 and Tau Proteins. T.S.M. Reijn, M.O. Rikkert, W.J.A. van Geel, D. de Jong, and M.M. Verbeek
859
The Brain Natriuretic Peptide (BNP) Precursor Is the Major Immunoreactive Form of BNP in Patients with Heart Failure. K.R. Seferian, N.N. Tamm, A.G. Semenov, K.S. Mukharyamova, A.A. Tolstaya, E.V. Koshkina, A.N. Kara, M.I. Krasnoselsky, F.S. Apple, T.V. Esakova, V.L. Filatov, and A.G. Katrukha
866
Multiple Biomarker Use for Detection of Adverse Events in Patients Presenting with Symptoms Suggestive of Acute Coronary Syndrome. F.S. Apple, L.A. Pearce, A. Chung, R. Ler, and M.M. Murakami
874
Clinical Chemistry (ISSN 0009-9147) is published monthly by the American Association for Clinical Chemistry, 1850 K Street, Suite 625, Washington, DC 20006. New subscriptions, renewals, changes of address, back issues, and all customer service questions should be addressed to: AACC, Subscription Department, 1850 K Street, Suite 625, Washington, DC 20006. Telephone (202) 857-0717 or 1 (800) 892-1400; fax (202) 887-5093; e-mail
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Clinical Chemistry May 2007 LIPOPROTEINS
AND
CARDIOVASCULAR RISK FACTORS
Prognostic Value of Cardiac Troponin T Is Independent of Inflammation, Residual Renal Function, and Cardiac Hypertrophy and Dysfunction in Peritoneal Dialysis Patients. A. Yee-Moon Wang, C. Wai-Kei Lam, M. Wang, I. Hiu-Shuen Chan, W.B. Goggins, C.-M. Yu, S.-F. Lui, and J.E. Sanderson
882
HEMATOLOGY Chronic Granulomatous Disease (CGD) and Complete Myeloperoxidase Deficiency Both Yield Strongly Reduced Dihydrorhodamine 123 Test Signals but Can Be Easily Discerned in Routine Testing for CGD. L. Mauch, A. Lun, M.R.G. O’Gorman, J.S. Harris, I. Schulze, A. Zychlinsky, T. Fuchs, U. Oelschla¨gel, S. Brenner, D. Kutter, A. Ro¨sen-Wolff, and J. Roesler
ENDOCRINOLOGY
AND
890
METABOLISM
Variability in the Relationship between Mean Plasma Glucose and HbA1c: Implications for the Assessment of Glycemic Control. E.S. Kilpatrick, A.S. Rigby, and S.L. Atkin
897
Simultaneous Quantification of Ghrelin and Desacyl-Ghrelin by Liquid Chromatography–Tandem Mass Spectrometry in Plasma, Serum, and Cell Supernatants. M. Rauh, M. Gro¨schl, and W. Rascher
902
A Direct Free Thyroxine (T4) Immunoassay with the Characteristics of a Total T4 Immunoassay. K.S. Fritz, R.B. Wilcox, and J.C. Nelson
911
Diagnostic Accuracy of Blood Lactate-to-Pyruvate Molar Ratio in the Differential Diagnosis of Congenital Lactic Acidosis. F.-G. Debray, G.A. Mitchell, P. Allard, B.H. Robinson, J.A. Hanley, and M. Lambert
916
AUTOMATION
AND
ANALYTICAL TECHNIQUES
Comparison of 11 Human Insulin Assays: Implications for Clinical Investigation and Research. S.E. Manley, I.M. Stratton, P.M. Clark, and S.D. Luzio
922
Multiplex Genotyping of Cytochrome P450 Single-Nucleotide Polymorphisms by Use of MALDI-TOF Mass Spectrometry. A. Misra, J.-Y. Hong, and S. Kim
933
GENERAL CLINICAL CHEMISTRY Gamma Glutamyltransferase and Long-Term Survival: Is It Just the Liver? L. Kazemi-Shirazi, G. Endler, S. Winkler, T. Schickbauer, O. Wagner, and C. Marsik
940
Quantification of Proteolytically Active Pregnancy-Associated Plasma Protein-A with an Assay Based on Quenched Fluorescence. C. Gyrup, M. Christiansen, and C. Oxvig
947
CLINICAL IMMUNOLOGY Cytokine Profiling in Human Colostrum and Milk by Protein Array. M. Kverka, J. Burianova, R. Lodinova-Zadnikova, I. Kocourkova, J. Cinova, L. Tuckova, and H. Tlaskalova-Hogenova
955
NUTRITION Detection of Vitamin B12 Deficiency in Older People by Measuring Vitamin B12 or the Active Fraction of Vitamin B12, Holotranscobalamin. R. Clarke, P. Sherliker, H. Hin, E. Nexo, A.M. Hvas, J. Schneede, J. Birks, P.M. Ueland, K. Emmens, J.M. Scott, A.M. Molloy, and J.G. Evans
OTHER AREAS
OF
CLINICAL CHEMISTRY
Genetic and Environmental Influences on Plasma Homocysteine: Results from a Danish Twin Study. L. Bathum, I. Petersen, L. Christiansen, A. Konieczna, T.I.A. Sørensen, and K.O. Kyvik
4A
963
(Continued)
971
Contents Volume 53, Number 5 TECHNICAL BRIEFS Evaluation of a New Pooling Strategy Based on Leukocyte Count for Rapid Quantification of Allele Frequencies. H. Rossmann, E. Bu¨chler, J.J. Wenzel, C. Neukirch, J.-B. du Prel, and K.J. Lackner
980
Perioperative Activin A Concentrations as a Predictive Marker of Neurologic Abnormalities in Children after Open Heart Surgery. P. Florio, R.F. Abella, T. de la Torre, A. Giamberti, S. Luisi, G. Butera, A. Cazzaniga, A. Frigiola, F. Petraglia, and D. Gazzolo
982
Quantifying Spurious Free T4 Results Attributable to Thyroxine-Binding Proteins in Serum Dialysates and Ultrafiltrates. K.S. Fritz, R.B. Wilcox, and J.C. Nelson
985
LETTERS
TO THE
EDITOR
Detection of Unexpected Isoforms of Human Chorionic Gonadotropin by Qualitative Tests. C.S. Sigel and D.G. Grenache
989
Novel Hemoglobin (Hb Grey Lynn) Substitution (␣91Leu3 Phe) Affects Heme Interactions and ␣12 Contacts. S.O. Brennan, T. Chan, and C. Sheen
990
A Multiplex Quantitative Fluorescent PCR Test for Prenatal Diagnosis of Hb Barts Hydrops Fetalis. D. Li
991
Reply. M. Choolani, S.H. Sze Yee, and S. Chong
992
Rapid Differential Diagnosis between Subarachnoid Hemorrhage and Traumatic Lumbar Puncture by D-Dimer Assay. M.L. Julia´-Sanchis, P.L. Estela-Burriel, F.J. Liro´n-Herna´ndez, and A. Guerrero-Espejo
993
Blood Lead Misclassification Due to Defective LeadCare® Blood Lead Testing Equipment. R.M. Bossarte, M.J. Brown, and R.L. Jones
994
Myocardial Infarction with Normal Coronary Arteries: A Role for MRI? M.W. Martinez, L. Babuin, I.S. Syed, D.-L. Feng, W.L. Miller, V. Mathew, J.F. Breen, and A.S. Jaffe
995
CORRECTION Identification of a New Metabolite of Astilbin, 3ⴕ-O-Methylastilbin, and Its Immunosuppressive Activity against Contact Dermatitis. J. Guo, F. Qian, J. Li, Q. Xu, and T. Chen 997
BOOK, SOFTWARE,
AND
WEB SITE REVIEWS
Understanding Clinical Papers, 2nd Edition. David Bowers, Allan House, and David Owens. A. Kallner
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FOR
READERS
OF
998
CLINICAL CHEMISTRY
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