Critical Care Medicine

Editorial Board

Critical Care Medicine

EDITOR-IN-CHIEF

ASSOCIATE EDITORS

SCIENTIFIC EDITORS

Timothy G. Buchman, PhD, MD, MCCM

Thomas P. Bleck, MD, MCCM, FNCS

Clifford S. Deutschman, MS, MD, MCCM

Director, Emory Critical Care Center Professor of Surgery Emory University School of Medicine Atlanta, Georgia

Professor of Neurological Sciences, Neurosurgery, Medicine, and Anesthesiology Rush Medical College Director of Clinical Neurophysiology Rush University Medical Center Chicago, Illinois

R. Phillip Dellinger, MD, MCCM Professor, Medicine Section of Critical Care Medicine Cooper Health System Camden, New Jersey

John C. Marshall, MD Professor of Surgery Saint Michael's Hospital Toronto, Ontario Canada

Henry Masur, MD, FCCM

Clinical Professor of Medicine George Washington University School of Medicine Chief, Critical Care Medicine Department NIH-Clinical Center, National Institutes of Health Bethesda, Maryland

Margaret M. Parker, MD, MCCM Professor, Pediatrics State University of New York at Stony Brook Stony Brook, New York

EDITORIAL OFFICE Managing Editor:

Sophie M. Tosta Director of Publications:

Katie Brobst Editorial Assistant:

Sarah Less SCCM 500 Midway Drive Mount Prospect, IL 60056 Phone: (847) 827-6869 Fax: (847) 827-6886 E-mail: [email protected] www.sccm.org

Jonathan E. Sevransky, MD, MHS, FCCM Director, Medical ICU Emory University Hospital Assistant Director for Medicine Emory Center for Critical Care Atlanta, Georgia

Vice Chair, Research Department of Pediatrics Professor of Pediatrics and Molecular Medicine Hofstra-Northwell School of Medicine The Feinstein Institute for Medical Research Manhasset, New York

Neil R. MacIntyre, MD

Professor, Medicine Duke University Medical Center Durham, North Carolina

Donald S. Prough, MD

Professor and Chairman Department of Anesthesiology University of Texas Medical Branch at Galveston Galveston, Texas

SENIOR EDITOR Jean-Louis Vincent, MD, PhD, FCCM Professor, Intensive Care Erasme University Hospital Brussels, Belgium

BOOK REVIEW EDITOR Jerry J. Zimmerman, MD, PhD, FCCM Faculty in Pediatric Critical Care Medicine Seattle Children’s Hospital, Harborview Medical Center University of Washington, School of Medicine Seattle, Washington

EDITORS EMERITI Joseph E. Parrillo, MD, MCCM Bart Chernow, MD, FCCM

FOUNDING EDITOR William C. Shoemaker, MD, MCCM

EDITORIAL BOARD MEMBERS Edward Abraham, MD, FCCM Professor and Dean Wake Forest School of Medicine Winston-Salem, North Carolina

Hasan B. Alam, MD, FACS

Norman W. Thompson Professor of Surgery Section Head, General Surgery University of Michigan Health System Ann Arbor, Michigan

Charles Cairns, MD

Dean, College of Medicine Professor, Department of Emergency Medicine Assistant Vice President, Clinical Research University of Arizona Health Sciences Tucson, Arizona

Cherylee W. Chang, MD, FCCM

Associate Clinical Professor Department of Medicine and Surgery The Queen's Medical Center, University of Hawaii, John Burns School of Medicine Honolulu, Hawaii

Davide Chiumello, MD Theodore A. Alston, MD, PhD

Department of Anesthesia, Critical Care, and Pain Medicine Massachusetts General Hospital Harvard Medical School Boston, Massachusetts

Yaseen Arabi, MD, FCCP, FCCM

Chairman, Intensive Care Department Professor, King Saud Bin Abdulaziz University Medical Director, Respiratory Services King Abdulaziz Medical City Ministry of National Guard Health Affairs Riyadh, Kingdom of Saudi Arabia

John H. Arnold, MD

Professor of Anaesthesia (Pediatrics) Harvard Medical School Senior Associate, Anesthesia and Critical Care Medical Director, Respiratory Care/ECMO Boston Children’s Hospital Boston, Massachusetts

Philip S. Barie, MD, MBA, MCCM Professor of Surgery and Public Health Weil Cornell Medical College New York, New York

Anish Bhardwaj, MD, MBA, CPE, FAHA, FCCM, FAAN, FANA Chairman, Department of Neurology John Sealy Chair of Neurology Professor, Neurology, Neurosurgery, Neuroscience and Cell Biology Associate Dean for Faculty Affairs and Professional Development University of Texas Medical Branch Galveston, Texas

Luca Bigatello, MD

Director, Surgical Critical Care St. Elizabeth’s Medical Center Professor of Anesthesiology Tufts University School of Medicine Boston, Massachusetts

Bruce R. Bistrian, MD, MPH, PhD Professor of Medicine Beth Israel Deaconess Medical Center Harvard Medical School Boston, Massachusetts

Direttore SC Anestesia e Rianimazione ASST Santi Paolo e Carlo Dipartimento di Scienze della Salute Universita degli Studi di Milano Milan, Italy

David A. Cook, PhD, FANZCA, FCICM Professor of Anaethesia and Critical Care Intensive Care Unit Princess Alexandra Hospital Brisbane, Australia

Craig M. Coopersmith, MD, FCCM Professor of Surgery Emory Center for Critical Care Emory University School of Medicine Atlanta, Georgia

Douglas B. Coursin, MD

Professor, Anesthesiology and Medicine University of Wisconsin School of Medicine and Public Health Madison, Wisconsin

Elliott Crouser, MD

Professor of Medicine Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine The Ohio State University Wexner Medical Center Columbus, Ohio

Joseph F. Dasta, MSc (Pharm), FCCP, MCCM Professor Emeritus Ohio State University Columbus, Ohio

Bennett deBoisblanc, MD Fred Allison, Jr, MD Professor of Medicine and Physiology Section of Pulmonary/Critical Care Medicine LSU Health Sciences Center, New Orleans New Orleans, Louisiana

John W. Devlin, PharmD, FCCP, FCCM Professor, Department of Pharmacy Practice Bouve College Northeastern University Special and Scientific Staff Division of Pulmonary, Critical Care and Sleep Medicine Critical Care Pharmacist Tufts Medical Center Boston, Massachusetts

Todd Dorman, MD

Senior Associate Dean for Education Coordination Associate Dean for CME Professor and Vice Chair for Critical Care Department of Anesthesiology and Critical Care Medicine Joint Appointments in Internal Medicine, Surgery, and the School of Nursing Johns Hopkins University School of Medicine Baltimore, Maryland

David J. Dries, MSE, MD, MCCM

Division Medical Director Regions Hospital and HealthPartners Medical Group St. Paul, Minnesota Professor of Surgery and Anesthesiology University of Minnesota Minneapolis, Minnesota

Philip A. Efron, MD, FACS, FCCM

Associate Professor, Departments of Surgery, Anesthesiology, Aging and Geriatric Research, and Molecular Genetics and Microbiology Co-Director, Laboratory of Inflammation Biology and Surgical Science Medical Director, Surgical and Trauma ICUs and Respiratory Care Department of Surgery Division of Acute Care Surgery and Surgical Critical Care Gainesville, Florida

Perenlei Enkhbaatar, MD, PhD, FAHA Professor, Department of Anesthesiology Director of Translational Intensive Care Unit Charles Robert Allen Professor in Anesthesiology University of Texas Medical Branch Galveston, Texas

Laura Evans, MD, MSc

Associate Professor NYU School of Medicine Medical Director of Critical Care, Bellevue Hospital Center New York, New York

J. Christopher Farmer, MD, FCCM Professor and Chair Department of Critical Care Medicine Mayo Clinic Phoenix, Arizona

Roy D. Goldfarb, PhD Professor Rowan University Glassboro, New Jersey

Editorial Board

Critical Care Medicine

Neil A. Halpern, MD, MCCM

John Kellum, MD, MCCM

Matthias Majetschak, MD, PhD

Maurene A. Harvey, RN, MPH, MCCM

Ruth M. Kleinpell, PhD, RN, FCCM

John J. Marini, MD

Professor, Anesthesiology and Medicine Weil Medical College of Cornell University Director, Critical Care Center Chief, Critical Care Medicine Memorial Sloan Kettering Cancer Center New York, New York Critical Care Educator and Consultant Lake Tahoe, Nevada

Thomas L. Higgins, MD, MBA, MCCM Chief Medical Officer Baystate Franklin Medical Center/Baystate Health Northern Region Greenfield, Massachusetts Baystate Noble Hospital Westfield, Massachusetts Professor of Medicine & Anesthesiology University of Massachusetts Medical School-Baystate Springfield, Massachusetts

Steven M. Hollenberg, MD, FCCM

Professor of Medicine Division of Cardiology Cooper Medical School of Rowan University Camden, New Jersey

Judith Jacobi, PharmD, BCPS, MCCM Critical Care Pharmacy Specialist Indiana University Health Methodist Hospital Indianapolis, Indiana

Marc G. Jeschke, MD, PhD, FACS, FRSCS, FCCM

Professor, University of Toronto Department of Surgery, Division of Plastic Surgery, Department of Immunology Director, Ross Tilley Burn Centre–Sunnybrook Health Sciences Centre Chair in Burn Research Senior Scientist, Sunnybrook Research Institute Toronto, Canada

Robert M. Kacmarek, PhD, FCCM Respiratory Care Massachusetts General Hospital Department of Anesthesiology Harvard Medical School Boston, Massachusetts

Andre Kalil, MD, MPH, FACP, FCCM Professor Department of Internal Medicine Division of Infectious Diseases University of Nebraska Medical Center Omaha, Nebraska

Sandra L. Kane-Gill, PharmD, MSc, FCCM

Associate Professor University of Pittsburgh School of Pharmacy and Clinical Translational Science Institute Pittsburgh, Pennsylvania

Professor of Critical Care Medicine Director, Center for Critical Care Nephrology Vice Chair for Research Department of Critical Care Medicine University of Pittsburgh Pittsburgh, Pennsylvania

Professor of Surgery and Molecular Pharmacology and Therapeutics Burn and Shock Trauma Research Institute Loyola University Chicago Stritch School of Medicine Maywood, Illinois

Director, Center for Clinical Research and Scholarship Rush University Medical Center Professor Rush University College of Nursing Nurse Practitioner Rush Lincoln Park Chicago, Illinois

Professor of Medicine University of Minnesota Regions Hospital Minneapolis/St. Paul, Minnesota

Michael Klompas, MD, MPH

Stanley A. Nasraway, MD, FCCM

Associate Professor Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute Department of Medicine Brigham and Women’s Hospital Boston, Massachusetts

Patrick M. Kochanek, MD, MCCM

Ake N. Grenvik Professor in Critical Care Medicine Professor and Vice Chair, Department of Critical Care Medicine Professor of Anesthesiology, Pediatrics, Bioengineering, and Clinical and Transitional Science Director, Safar Center for Resuscitation Research University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania

Marin H. Kollef, MD

Virginia E. and Sam J. Golman Chair in Respiratory Intensive Care Medicine Professor of Medicine Division of Pulmonary and Critical Care Medicine Washington University School of Medicine Director, Critical Care Research Director, Respiratory Care Services Barnes-Jewish Hospital St. Louis, Missouri

Andreas Hans-Joachim Kramer, MD, MSc Clinical Assistant Professor Department of Critical Care Medicine University of Calgary Hotchkiss Brain Institute Calgary, Alberta, Canada

Ishaq Lat, PharmD, FCCM, FCCP Associate Director, Clinical Services Clinical Specialist, Critical Care Rush University Medical Center Chicago, Illinois

Flavia R. Machado, PhD

Universidade Federal de Sao Paulo Sao Paulo, Brazil

Lauralyn A. McIntyre, MD, MSc The Ottawa Hospital Ottawa, Ontario, Canada

Professor of Surgery, Medicine, and Anesthesiology Tufts University School of Medicine Director, Surgical Intensive Care Units Department of Surgery Tufts Medical Center Boston, Massachusetts

Michael S. Niederman, MD, FCCM

Weill Cornell Medical College Clinical Director, Pulmonary and Critical Care Medicine New York Presbyterian Hospital-Weill Cornell Medical Center New York, New York

Paul A. Nyquist, MD

The Johns Hopkins Hospital Departments of Neurology, Anesthesiology & Critical Care Medicine, and Neurosurgery Baltimore, Maryland

John M. Oropello, MD, FACP, FCCP, FCCM Professor of Surgery and Medicine Program Director Critical Care Medicine, co-Director SICU Icahn School of Medicine at Mount Sinai New York, New York

Tiffany M. Osborn, MD, MPH

Associate Professor Department of Surgery and Division of Emergency Medicine Section of Acute and Critical Care Surgery Surgical/Trauma Critical Care Barnes Jewish Hospital Washington University St. Louis, Missouri

Robert I. Parker, MD

Professor and Director of Pediatric Hematology/Oncology Stony Brook University School of Medicine Stony Brook, New York

Stephen M. Pastores, MD, FCCM

Professor, Anesthesiology and Medicine Weil Medical College of Cornell University Program Director, Critical Care Medicine Memorial Sloan Kettering Cancer Center New York, New York

Murray M. Pollack, MD, FCCM

Professor of Pediatrics Children’s National Medical Center George Washington University School of Medicine and Health Sciences Washington, DC

David T. Porembka, DO, MCCM

Professor of Surgery and Anesthesiology Case Western Reserve University School of Medicine MetroHealth Medical Center Cleveland, Ohio

Hallie C. Prescott, MD, MSc

Assistant Professor of Internal Medicine VA Ann Arbor Healthcare System University of Michigan Ann Arbor, Michigan

Kenneth G. Proctor, PhD

Professor of Surgery and Anesthesiology Divisions of Trauma and Surgical Critical Care Daughtry Family Department of Surgery University of Miami Miller School of Medicine Miami, Florida

Richard H. Savel, MD, FCCM

Director, Adult Critical Care Services Maimonides Medical Center Professor of Clinical Medicine and Neurology SUNY Downstate College of Medicine Brooklyn, New York

Christopher W. Seymour, MD, MSc

Assistant Professor of Critical Care Medicine and Emergency Medicine University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania

Andrew Shorr, MD

Director, Medical Intensive Care Unit Medstar Washington Hospital Center Potomac, Maryland

Mark D. Siegel, MD, FCCP, FACP

Professor of Internal Medicine Section of Pulmonary, Critical Care and Sleep Medicine Program Director, Traditional Internal Medicine Residency Yale School of Medicine New Haven, Connecticut

Zoltan Spolarics, MD, PhD

Professor Department of Surgery Rutgers Biomedical and Health Sciences New Jersey Medical School Newark, New Jersey

Charles L. Sprung, MD, JD, MCCM

Professor of Medicine and Critical Care Medicine Hadassah Hebrew University Medical Center Jerusalem, Israel

Paul Steendijk, PhD

Associate Professor of Cardiovascular Physiology Department of Cardiology Leiden University Medical Center Leiden, The Netherlands

Wolfgang Steudel, MD CEO Team Approach Inc. Boston, Massachusetts San Jose, California

Robert D. Stevens, MD

Associate Professor of Anesthesiology, Critical Care Medicine, Neurology, Neurosurgery, and Radiology Johns Hopkins University School of Medicine Baltimore, Maryland

Daniel A. Sweeney, MD

Assistant Professor Division of Pulmonary, Critical Care and Sleep Medicine Department of Internal Medicine University of California, San Diego La Jolla, California

Daniel Talmor, MD, FCCM

Professor of Anaesthesia Beth Israel Deaconess Medical Center Harvard Medical Center Boston, Massachusetts

Wanchun Tang, MD, MCCM Director Weil Institute of Emergency and Critical Care Medicine Department of Emergency Medicine Virginia Commonwealth University School of Medicine Richmond, Virginia Richard Teplick, MD

Adjunct Professor of Medicine University of South Alabama Mobile, Alabama

Ravi Thiagarajan, MBBS, MPH Senior Associate in Cardiology Cardiovascular Critical Care Boston Children’s Hospital Associate Professor of Pediatrics Harvard Medical School Boston, Massachusetts

Samuel A. Tisherman, MD, FACS, FCCM

Professor, Department of Surgery and the Program in Trauma University of Maryland School of Medicine Director, Center for Critical Care and Trauma Education Baltimore, Maryland

Stephen Trzeciak, MD, MPH Professor and Head of Critical Care Medicine Medical Director, Center for Critical Care Services Cooper University Health Care Cooper Medical School of Rowan University Camden, New Jersey

Luis Ulloa, PhD

Associate Professor Rutgers—New Jersey Medical School Rutgers University Newark, New Jersery

Paul M. Vespa, MD, FCCM

Director of Neurocritical Care Professor of Neurosurgery and Neurology University of California Los Angeles Geffen School of Medicine Los Angeles, California

Mark Wainwright, MD, PhD

Founders’ Board Chair in Neurocritical Care Departments of Pediatrics and Neurology Northwestern University Feinberg School of Medicine Chicago, Illinois

Michaela A. West, MD, PhD, FCCM Trauma Research Chair North Memorial Health Care Adjunct Professor of Surgery Department of Surgery University of Minnesota Robbinsdale, Minnesota

Hector R. Wong, MD

Director, Division of Critical Care Medicine Cincinnati Children’s Hospital Medical Center and Cincinnati Children’s Research Foundation Professor of Pediatrics Department of Pediatrics University of Cincinnati College of Medicine Cincinnati, Ohio

Marya Zilberberg, MD, MPH, FCCP

President and CEO Evi Med Research Group, LLC School of Public Health and Health Sciences University of Massachusetts Worcester, Massachusetts

Basilia Zingarelli, MD, PhD

Director of Basic Science Research Division of Critical Care Medicine Cincinnati Children’s Hospital Medical Center Professor of Pediatrics Department of Pediatrics University of Cincinnati College of Medicine Cincinnati, Ohio