Biol Trace Elem Res DOI 10.1007/s12011-013-9803-8
Decreased Serum Selenium Levels are Correlated with Diminished Coronary Flow Reserve Among Hemodialysis Patients Aydin Atakan & Beyza Macunluoglu & Yuksel Kaya & Elif Ari & Halit Demir & Ebru Asicioglu & Cigdem Kaspar
Received: 30 May 2013 / Accepted: 23 August 2013 # Springer Science+Business Media New York 2013
Abstract Cardiovascular diseases are the main reason of high mortality among hemodialysis patients. Decreased serum selenium levels may have a role in accelerated atherosclerosis in this patient group. The hypothesis of this study was to show a correlation between decreased serum selenium levels and coronary flow reserve as an indicator of endothelial dysfunction and atherosclerosis in HD patients. A. Atakan (*) Department of Nephrology, Fatih Sultan Mehmet State Hospital, 34000 Istanbul, Turkey e-mail:
[email protected] B. Macunluoglu Department of Nephrology, Uskudar State Hospital, 34000 Istanbul, Turkey e-mail:
[email protected] Y. Kaya Department of Cardiology, Van Yuksek Ihtisas Hospital, 65200 Van, Turkey e-mail:
[email protected] E. Ari Department of Nephrology, Van Yuksek Ihtisas Hospital, 65200 Van, Turkey e-mail:
[email protected] H. Demir Department of Biochemistry, Yuzuncu Yil University, 65000 Van, Turkey e-mail:
[email protected] E. Asicioglu Department of Nephrology, Marmara University, 34662 Istanbul, Turkey e-mail:
[email protected] C. Kaspar Department of Biostatistics, Yeditepe University, 34000 İstanbul, Turkey e-mail:
[email protected]
Seventy-one chronic hemodialysis patients and age 65 and sex-matched healthy controls were included in the study. Plasma selenium levels were measured by spectrophotometry, and coronary flow reserve was assessed by transthoracic Doppler echocardiography. Serum selenium levels (34.16± 6.15 ng/ml vs. 52.4±5.51 ng/ml, P
