Articles in PresS. J Appl Physiol (December 1, 2005). doi:10.1152/japplphysiol.00779.2005
Distribution and function of muscarinic receptor subtypes in the ovine submandibular gland
By G. Tobin*#, A.T. Ryberg*, S. Gentle§ and the late A.V. Edwards§
*Department of Pharmacology, the Sahlgrenska Academy at Göteborg University, Medicinaregatan 15D, Goteborg 413 90, Sweden and §Physiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK
Running title: Muscarinic receptors in the ovine submandibular gland
Keywords: saliva, vasodilatation, muscarinic receptor
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Corresponding author:
[email protected]
1 Copyright © 2005 by the American Physiological Society.
The effects of muscarinic receptor antagonists on responses to electrical stimulation of the chorda-lingual nerve were determined in pentobarbitone-anaesthetized sheep and correlated to the morphology of tissue specimens. Stimulation at 2 Hz continuously, or in bursts of 1 s at 20 Hz every 10 s, for 10 min induced similar submandibular fluid responses (19±3 vs. 21±3 l.min-1 g gland-1), while vasodilatation was greater during stimulation in bursts (-52±4 vs. -43±5 %; P
