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Plasma Malondialdehyde (MDA)…
Atiba A et al
479
ORIGINAL ARTICLE
Plasma Malondialdehyde (MDA): An Indication of Liver Damage in Women with Pre-Eclamsia Adeniran S Atiba 1, Fayeofori M Abbiyesuku2, Dolapo P Oparinde3, Temitope A ‘Niran-Atiba4, Rasaq A Akindele5 ABSTRACT BACKGROUND: One of the features associated with pre-eclampsia is elevated liver transaminases. The reason this happens has not been fully described. However, the hepatocytes are not known to be spared by free radical injury. This study was conducted to examine the relationship between product of free radical injury (malondialdehyde) and transaminases in pre-eclamptic women. PATIENTS AND METHODS: A total of 98 and 115 pre-eclamptic and apparently normal pregnant women were selected from the booking clinic of Ladoke Akintola University of Technology Teaching Hospital, Osogbo. Non-pregnant women were selected from volunteered members of staff. Malondialdehyde (MDA), aspartate transaminase (AST) and alanine transaminase (ALT) analyses were determined on collected venous blood sample. Statistical analyses of variables were done using SPSS 17 taking level of significance to be p0.05) in age of the study groups. There was no statistically significant difference (p>0.05) also in the mean values of body mass index within the groups. There was no statistically significant difference (p>0.05) in systolic blood pressure (SBP) (mmHg) among the study groups. Similar findings were observed in diastolic blood pressure (DBP) (mmHg).
Plasma Malondialdehyde (MDA)…
Atiba A et al
481
Table 1: Comparison of Mean±SD of Clinical Variables/Parameters Variables Age (year)
Comparison NonP Vs NP NonP Vs PE NP Vs PE NonP Vs NP NonP Vs PE NP Vs PE
Mean ±SD 25.26±5.32 Vs 28.87±6.62 25.26±5.32 Vs 28.87±4.33 28.87±6.62 Vs 28.87±4.33 24.32±4.14 Vs 23.46±4.38 24.32±4.14 Vs 24.60±3.50 23.46±4.38 Vs 24.60±3.50
p-Values >0.05 >0.05 >0.05 >0.05 >0.05 >0.05
GA (week)
NP Vs PE
24.28±5.81 Vs 24.03±1.73
>0.05
SBP (mmHg)
NonP Vs NP NonP Vs PE NP Vs PE
121.60±12.20 Vs 117.83±13.03 121.60±12.20 Vs 166.15±9.40 117.83±13.03 Vs 166.15±9.40
