International STD Research & Reviews 3(1): 14-22, 2015; Article no.ISRR.2015.003 ISSN: 2347-5196
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Effect of HIV Infection and Antiretroviral Therapy Duration on CD4 Count, Total and Differential White Cell Count C. O. Okeke1*, G. I. Amilo2, M. O. Ifeanyichukwu1, E. O. Obi3, A. C. Okeke1 and N. C. Ibeh1 1
Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka, Nnewi Campus P.M.B. 5001 Anambra State, Nigeria. 2 Department of Haematology, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nnewi Campus P.M.B. 5001 Anambra State, Nigeria. 3 Department of Pharmacology and Therapeutics, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nnewi Campus P.M.B. 5001 Anambra State, Nigeria. Authors’ contributions This work was carried out in collaboration between all authors. Authors COO and GIA designed the study. Author COO wrote the protocol, and wrote the first draft of the manuscript. Author COO managed the literature searches and the experimental process and authors COO and MOI managed the statistical analysis. Authors EOO, ACO, NCI carried out manuscript revision. All authors approved the final manuscript. Article Information DOI: 10.9734/ISRR/2015/12358 Editor(s): (1) Ma Luo, National Microbiology Lab, Public Health Agency of Canada, Canada And Department of Medical Microbiology, University of Manitoba, Canada. Reviewers: (1) Anonymous, University of Milan, Italy. (2) Anonymous, University of the West Indies, Jamaica. (3) Jennifer A. Robinson, Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine, USA. (4) Anonymous, National Institute for Communicable Diseases, South Africa. (5) Anonymous, Tehran University of Medical Sciences, Iran. (6) Anonymous, University of the Witwatersrand, Johannesburg, South Africa. (7) Jun Gong, Internal Medicine, Cedars-Sinai Medical Center, USA. Complete Peer review History: http://www.sciencedomain.org/review-history.php?iid=646&id=27&aid=7547
th
Original Research Article
Received 28 June 2014 Accepted 12th December 2014 th Published 27 December 2014
ABSTRACT Aims: To assess CD4 counts, total and differential white cell counts in HIV positive patients on antiretroviral treatment (ART) and those not on antiretroviral treatments with varying durations of _____________________________________________________________________________________________________ *Corresponding author: Email:
[email protected];
Okeke et al.; ISRR, 3(1): 14-22, 2015; Article no.ISRR.2015.003
infection. Study Design: Case-control study. Place and Duration of Study: Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria from March to August 2013. Methodology: We included 181 subjects; sixty HIV patients on ART with infection duration of 5 – 8 and >8 – 17 years and ART duration of 5 – 8 and >8 – 17 years; sixty HIV patients not on ART with an infection duration of 3 – 6 and >6 – 11years; and sixty-one apparently healthy individuals control. CD4 counts, total and differential white cell counts as well as Human Immunodeficiency virus (HIV) status were determined. Results: CD4 counts was significantly higher in the control compared to the ART and non-ART and lower in HIV duration of 3 – 6 years and >6 – 11 years (P
