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IJPBS |Volume 3| Issue 3 |JUL-SEP|2013|278-284
Research Article Biological Sciences Effect of Lithium Therapy on Non-enzymatic Antioxidants in Patients with Bipolar Affective Disorder Raju Kumar Dubey1*, Seraj Ahmed Khan2, Youbraj Neupane1, Pramod Mohan Shyangwa3, Nirmal Baral2, Madhab Lamsal2 Department of Biochemistry Universal College of Medical Sciences, Bhairahawa, Nepal, 2 B.P. Koirala Institute of Health Sciences, Dharan, Nepal, 3 Department of Psychiatry, B.P. Koirala Institute of Health Sciences, Dharan, Nepal 1
*Corresponding Author Email:
[email protected]
ABSTRACT Aim: Brain is more vulnerable to oxidative free radicals than other tissues. Oxidative stress might primarily or secondarily be involved in the pathogenesis of bipolar affective disorder. Therefore this study was aimed to estimate & compare parameters of oxidative stress and antioxidant levels in bipolar patients and healthy controls. Methods: A total of 32 bipolar patients and 30 healthy subjects were recruited in this study. Serum MDA level was measured as indicator of lipid peroxidation and vitamin C, E & glutathione were determined as a measure of antioxidant status. Results: Significantly (p
